Therapeutic angiogenesis is an experimental frontier in vascular biology that seeks to
deliver angiogenic growth factors to ischemic or injured tissues to promote targeted …

VEGF is an important mediator of pathological angiogenesis in the eye and is a target for the
development of novel anti-angiogenic molecules. In a previous study we identified 12-amino …

Angiogenesis, the formation of new capillaries from existing vasculature, plays an essential
role in tissue repair. The rapid onset and predominance of proangiogenic factors optimizes …

Modulating angiogenesis is an attractive goal because many pathological conditions
depend on the growth of new vessels. Angiogenesis is mainly regulated by the VEGF, a …

Neuropilin (NRP) 1, previously identified as a neuronal receptor that mediates repulsive
growth cone guidance, has been shown recently to function also in endothelial cells as an …

VEGF receptors have been the target of intense research aimed to develop molecules able
to inhibit or stimulate angiogenesis. Based on the x-ray structure of the complex placental …

Angiogenesis, or formation of new blood vessels, is crucial to cancer tumor growth. Tumor
growth, progression, and metastasis are critically influenced by the production of the pro …

Vascular endothelial growth factor (VEGF) binding to the kinase domain receptor
(KDR/FLK1 or VEGFR‐2) mediates vascularization and tumor‐induced angiogenesis. Since …

Neuropilin-1 (NRP-1) is present on the cell surface of endothelial cells, or as a soluble
truncated variant. Membrane NRP-1 is proposed to enhance angiogenesis by promoting the …

Vascular endothelial growth factor (VEGF) is the main regulator of physiological and
pathological angiogenesis. Low molecular weight molecules able to stimulate angiogenesis …