Short-term metabolic disruptions in urine of mouse models following exposure to low doses of oxygen ion radiation

M Girgis, Y Li, M Jayatilake, K Gill, S Wang… - … Science and Health …, 2021 - Taylor & Francis
Molecular alterations as a result of exposure to low doses of high linear energy transfer
(LET) radiation can have deleterious short-and long-term consequences on crew members …

Metabolomic profiling of urine samples from mice exposed to protons reveals radiation quality and dose specific differences

EC Laiakis, D Trani, BH Moon, SJ Strawn… - Radiation …, 2015 - meridian.allenpress.com
As space travel is expanding to include private tourism and travel beyond low-Earth orbit, so
is the risk of exposure to space radiation. Galactic cosmic rays and solar particle events …

Longitudinal metabolic alterations in plasma of rats exposed to low doses of high linear energy transfer radiation

T Dissmore, AG DeMarco, M Jayatilake… - … Science and Health …, 2021 - Taylor & Francis
Astronauts embarking on deep space missions are at high risk of long-term exposure to low
doses of high linear energy transfer (LET) radiation, which can contribute to the …

Biofluid Metabolomics of Mice Exposed to External Low-Dose Rate Radiation in a Novel Irradiation System, the Variable Dose-Rate External 137Cs Irradiator

EL Pannkuk, EC Laiakis, M Girgis… - Journal of proteome …, 2021 - ACS Publications
An important component of ionizing radiation (IR) exposure after a radiological incident may
include low-dose rate (LDR) exposures either externally or internally, such as from 137Cs …

Metabolic dysregulation after neutron exposures expected from an improvised nuclear device

EC Laiakis, YW Wang, EF Young… - Radiation …, 2017 - meridian.allenpress.com
The increased threat of terrorism across the globe has raised fears that certain groups will
acquire and use radioactive materials to inflict maximum damage. In the event that an …

Plasma metabolomic signatures from patients following high-dose total body irradiation

X Hong, L Tian, Q Wu, L Gu, W Wang, H Wu, M Zhao… - Molecular …, 2023 - pubs.rsc.org
Despite some advances in the study of radiation injuries, effective methods of prevention
and treatment of severe acute radiation syndrome or illness (ARS) are still lacking …

Gas chromatography/mass spectrometry metabolomics of urine and serum from nonhuman primates exposed to ionizing radiation: Impacts on the tricarboxylic acid …

EL Pannkuk, EC Laiakis, S Authier… - Journal of proteome …, 2017 - ACS Publications
Ionizing radiation (IR) directly damages cells and tissues or indirectly damages them
through reactive free radicals that may lead to longer term adverse sequelae such as …

[HTML][HTML] Temporal effects on radiation responses in nonhuman primates: identification of biofluid small molecule signatures by gas chromatography–mass …

EL Pannkuk, EC Laiakis, M Girgis, SE Dowd… - Metabolites, 2019 - mdpi.com
Whole body exposure to ionizing radiation damages tissues leading to physical symptoms
which contribute to acute radiation syndrome. Radiation biodosimetry aims to determine …

Radiation metabolomics. 2. Dose-and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice

JB Tyburski, AD Patterson, KW Krausz… - Radiation …, 2009 - meridian.allenpress.com
Abstract Tyburski, JB, Patterson, AD, Krausz, KW, Slavík, J., Fornace, AJ Jr., Gonzalez, FJ
and Idle, JR Radiation Metabolomics. 2. Dose-and Time-Dependent Urinary Excretion of …

[HTML][HTML] Identification of plasma lipidome changes associated with low dose space-type radiation exposure in a murine model

M Upadhyay, M Rajagopal, K Gill, Y Li, S Bansal… - Metabolites, 2020 - mdpi.com
Long-term exposures to low dose space radiation may have adverse effects on human
health during missions in deep space. Conventional dosimetry, monitoring of prodromal …