AMP-activated protein kinase (AMPK) functions as an energy sensor to provide metabolic
adaptations under the ATP-deprived conditions such as hypoxia. In the present study, we …

The key transcription factor that regulates the cellular responses to hypoxia is hypoxia
inducible factor-1 (HIF-1). The signaling mechanisms that regulate the hypoxic activation of …

Abstract Hypoxia-inducible factor (HIF-1) plays a central role in the cellular adaptive
response to hypoxic conditions, which are closely related to pathophysiological conditions …

Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding proteins that
enable cells to adapt to reduced O2 availability. Proteins encoded by HIF-1 target genes …

The hypoxia-inducible factor 1 (HIF-1) transcriptional complex is regulated by cellular
oxygen levels and growth factors. The phosphoinosotide 3-kinase (PI-3K)-Akt/protein kinase …

Hypoxia-inducible factors (HIF) are a family of heterodimeric transcriptional regulators that
play pivotal roles in the regulation of cellular utilization of oxygen and glucose and are …

Low oxygen gradients (hypoxia and anoxia) are important determinants of pathological
conditions under which the tissue blood supply is deficient or defective, such as in solid …

Intermittent hypoxia (IH) occurs in many pathological conditions. However, very little is
known about the molecular mechanisms associated with IH. Hypoxia-inducible factor 1 (HIF …

Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic
conditions. Regulation of expression and activity of its inducible subunit, HIF-1α, involves …

Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response
to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low …