Purpose: Cerebral ischemia/reperfusion (I/R) injury causes hippocampal apoptosis and
cognitive impairment, and the dysfunction of gap junction intercellular communication (GJIC) …

Ischemic stroke often causes motor and cognitive deficits. Deregulated glia gap junction
communication, which is reflected by increased protein levels of glial fibrillary acidic protein …

Gap junction communication between astrocytes plays an important role in the brain. The
purpose of this study was to investigate the effects of Gingko biloba extract (GBE) on the …

Neuroinflammation is closely related to prognosis in ischemic stroke. Microglia are the main
immune cells in the nervous system. Under physiological conditions, microglia participate in …

Current studies demonstrated that cell survival is determined by a balance among signaling
cascades, including those that recruit the Akt and JNK pathways. In our present work, the …

Insulin-like growth factor 1 (IGF-1) has neuroprotective actions, including vasodilatory, anti-
inflammatory, and antithrombotic effects, following ischemic stroke. However, the molecular …

Stroke is a leading cause of disability and death in the worldwide. Therefore, prevention of
stroke is critically important. Genistein, a natural phytoestrogen extracted from soybeans …

Background: Hundreds of previous studies demonstrated the cytoprotective effect of
trichostatin-A (TSA), a kind of histone deacetylases inhibitors (HDACIs), against cerebral …

Although Metformin, a first-line antidiabetic drug, can ameliorate ischemia/reperfusion (I/R)
induced brain damage, but how metformin benefits injured hippocampus and the …

Apoptosis is the main pathological aspect of neuronal injury after cerebral ischemia–
reperfusion (I/R) injury. However the detailed molecular mediators are still under debate …