The development and maintenance of resident macrophages

EG Perdiguero, F Geissmann - Nature immunology, 2016 - nature.com
The molecular and cellular mechanisms that underlie the many roles of macrophages in
health and disease states in vivo remain poorly understood. The purpose of this Review is to …

Tissue-resident macrophages originate from yolk sac-derived erythro-myeloid progenitors

EG Perdiguero, K Klapproth, C Schulz… - Experimental …, 2015 - exphem.org
Macrophages are phagocytic cells that orchestrate homeostatic and innate immune
functions, via the scavenging of cells, debris, and pathogens, and the production of …

Physiology and diseases of tissue-resident macrophages

T Lazarov, S Juarez-Carreño, N Cox, F Geissmann - Nature, 2023 - nature.com
Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …

Macrophages: sentinels and regulators of the immune system

L Franken, M Schiwon, C Kurts - Cellular microbiology, 2016 - Wiley Online Library
The important role of macrophages in host defense against a variety of pathogens has long
been recognized and has been documented and reviewed in numerous publications …

Ontogeny of tissue-resident macrophages

G Hoeffel, F Ginhoux - Frontiers in immunology, 2015 - frontiersin.org
The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has
remained controversial until recently. Originally described as part of the mononuclear …

Tissue-resident macrophage development and function

Y Wu, KK Hirschi - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Tissue-resident macrophages have been associated with important and diverse biological
processes such as native immunity, tissue homeostasis and angiogenesis during …

The origins and homeostasis of monocytes and tissue‐resident macrophages in physiological situation

Y Zhao, W Zou, J Du, Y Zhao - Journal of cellular physiology, 2018 - Wiley Online Library
Monocytes and macrophages are critical effectors and regulators of innate immune
response. They not only play crucial and distinctive roles in homeostasis, but also contribute …

Monocytes and macrophages: developmental pathways and tissue homeostasis

F Ginhoux, S Jung - Nature Reviews Immunology, 2014 - nature.com
Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and
immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive …

Delineating the origins, developmental programs and homeostatic functions of tissue-resident macrophages

E Mass - International Immunology, 2018 - academic.oup.com
A literature covering 150 years of research indicates that macrophages are a diverse family
of professional phagocytes that continuously explore their environment, recognize and …

Tissue macrophage identity and self‐renewal

R Gentek, K Molawi, MH Sieweke - Immunological reviews, 2014 - Wiley Online Library
Macrophages are cellular components of the innate immune system that reside in virtually
all tissues and contribute to immunity, repair, and homeostasis. The traditional view that all …