Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

R Suzuki, D Yamasoba, I Kimura, L Wang, M Kishimoto… - Nature, 2022 - nature.com
The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern. In
this study, our statistical modelling suggests that Omicron has spread more rapidly than the …

Attenuated replication and pathogenicity of SARS-CoV-2 B. 1.1. 529 Omicron

H Shuai, JFW Chan, B Hu, Y Chai, TTT Yuen, F Yin… - Nature, 2022 - nature.com
Abstract The Omicron (B. 1.1. 529) variant of SARS-CoV-2 emerged in November 2021 and
is rapidly spreading among the human population. Although recent reports reveal that the …

Evolution of the SARS‐CoV‐2 omicron variants BA. 1 to BA. 5: implications for immune escape and transmission

LB Shrestha, C Foster, W Rawlinson… - Reviews in Medical …, 2022 - Wiley Online Library
The first dominant SARS‐CoV‐2 Omicron variant BA. 1 harbours 35 mutations in its Spike
protein from the original SARS‐CoV‐2 variant that emerged late 2019. Soon after its …

Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation

DY Chen, CV Chin, D Kenney, AH Tavares, N Khan… - Nature, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …

Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron

JM Carreño, H Alshammary, J Tcheou, G Singh… - Nature, 2022 - nature.com
Abstract The Omicron (B. 1.1. 529) variant of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) was initially identified in November 2021 in South Africa and Botswana, as …

SARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype

SB Park, M Khan, SC Chiliveri, X Hu, P Irvin… - Communications …, 2023 - nature.com
Since the emergence of the Omicron variants at the end of 2021, they quickly became the
dominant variants globally. The Omicron variants may be more easily transmitted compared …

Omicron makes a feeble attack on the lungs

M Kozlov - Nature, 2022 - nature.com
Early indications from South Africa and the United Kingdom signal that the fast-spreading
Omicron variant of the coronavirus SARS-CoV-2 is less dangerous than its predecessor …

Reduced pathogenicity of the SARS-CoV-2 omicron variant in hamsters

K McMahan, V Giffin, LH Tostanoski, B Chung… - Med, 2022 - cell.com
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
(B. 1.1. 529) variant has proven to be highly transmissible and has outcompeted the Delta …

Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents

C Ma, X Chen, F Mei, Q Xiong, Q Liu… - Emerging microbes & …, 2022 - Taylor & Francis
Global concern has been raised by the emergence and rapid transmission of the heavily
mutated SARS-CoV-2 Omicron variant (B. 1.1. 529). So far, the infection features and …

SARS-CoV-2 Omicron spike H655Y mutation is responsible for enhancement of the endosomal entry pathway and reduction of cell surface entry pathways

M Yamamoto, K Tomita, Y Hirayama, J Inoue… - BioRxiv, 2022 - biorxiv.org
Abstract The SARS-CoV-2 Omicron variant reportedly displays decreased usage of the cell
surface entry pathway mediated by the host transmembrane protease, serine 2 (TMPRSS2) …