Visit-to-visit blood pressure variability and longitudinal tau accumulation in older adults
Background: Elevated blood pressure variability (BPV) is predictive of dementia,
independent of average blood pressure levels, but neuropathological mechanisms remain …
independent of average blood pressure levels, but neuropathological mechanisms remain …
Visit-to-visit blood pressure variability and CSF Alzheimer disease biomarkers in cognitively unimpaired and mildly impaired older adults
Background and Objectives Blood pressure variability is an emerging risk factor for cognitive
decline and dementia, but mechanisms remain unclear. The current study examined …
decline and dementia, but mechanisms remain unclear. The current study examined …
[HTML][HTML] Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers
Blood pressure variability is an emerging risk factor for dementia but relationships with
markers of neurodegeneration and Alzheimer's disease risk are understudied. We …
markers of neurodegeneration and Alzheimer's disease risk are understudied. We …
Blood pressure variability and plasma Alzheimer's disease biomarkers in the SPRINT trial
Background: Recent observational studies suggest higher blood pressure (BP) variability
(BPV) is associated with Alzheimer's disease (AD) biomarkers amyloid-beta (Aβ) and tau …
(BPV) is associated with Alzheimer's disease (AD) biomarkers amyloid-beta (Aβ) and tau …
Long-term blood pressure variability across the clinical and biomarker spectrum of Alzheimer's disease
Background: Elevated blood pressure is linked to cognitive impairment and Alzheimer's
disease (AD) biomarker abnormality. However, blood pressure levels vary over time. Less is …
disease (AD) biomarker abnormality. However, blood pressure levels vary over time. Less is …
Tau pathologies mediate the association of blood pressure with cognitive impairment in adults without dementia: the CABLE study
H Hu, L Meng, YL Bi, W Zhang, W Xu… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction This study delineated the interrelationships among blood pressure (BP),
cerebrospinal fluid (CSF) core biomarkers of Alzheimer's disease (AD), and cognition …
cerebrospinal fluid (CSF) core biomarkers of Alzheimer's disease (AD), and cognition …
Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults
Blood pressure variability (BPV) is linked to dementia risk, possibly through cerebral
hypoperfusion. We investigated BPV over 1 year and concurrent regional cerebral perfusion …
hypoperfusion. We investigated BPV over 1 year and concurrent regional cerebral perfusion …
Visit-to-visit blood pressure variability, neuropathology, and cognitive decline
Objective Large systolic blood pressure (SBP) variability has been proposed as a novel risk
factor for dementia above and beyond SBP levels, but the underlying neuropathology is …
factor for dementia above and beyond SBP levels, but the underlying neuropathology is …
[HTML][HTML] Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology
T Kim, D Yi, MS Byun, H Ahn, JH Jung, N Kong… - Alzheimer's research & …, 2022 - Springer
Background Hypertension has been associated with Alzheimer's disease (AD) dementia as
well as vascular dementia. However, the underlying neuropathological changes that link …
well as vascular dementia. However, the underlying neuropathological changes that link …
Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly
L Glodzik, H Rusinek, E Pirraglia, P McHugh… - Neurobiology of …, 2014 - Elsevier
In hypertension (HTN), cerebral blood flow regulation limits are changed, and the threshold
for blood pressure (BP) at which perfusion is safely maintained is higher. This shift may …
for blood pressure (BP) at which perfusion is safely maintained is higher. This shift may …