The cyclin D binding myb-like transcription factor 1 (DMTF1) is a tumor suppressor gene that
activates p14 ARF transcription and thereby stabilizing the p53 tumor suppressor. The …

The cyclin D binding myb‑like transcription factor 1 (DMTF1), a haplo‑insufficient tumor
suppressor gene, has 3 alternatively spliced mRNA isoforms encoding DMTF1α, β and γ …

We have previously shown that hydrogen peroxide–resistant permanent (OC-14) cells are
resistant to the cytotoxicity of several exogenous oxidative and anticancer agents including …

Dmp1 (cyclin D-interacting myb-like protein 1; also called Dmtf1) is a transcription factor that
has been isolated in a yeast two-hybrid screen through its binding property to cyclin D2 …

Dmp1 (cyclin D binding myb-like protein 1; also called Dmtf1) is a transcription factor that
was isolated in a yeast two-hybrid screen through its binding property to cyclin D2. Although …

Chemotherapy using DNA intercalators is one of the most successful approaches to cancer
treatment. Although DNA intercalators are believed to inhibit DNA polymerases and …

Abstract The human DMTF1 (DMP1) transcription factor, a DNA binding protein that interacts
with cyclin D, is a positive regulator of the p14ARF (ARF) tumor suppressor. Our earlier …

Purpose: MDM2 is a key negative regulator of the p53 signaling pathway. We aimed to
evaluate the inter-relationships between MDM2 SNP309, mRNA expression, amplification …

MDM2 proto-oncogene expression is aberrant in many human tumors. Its normal role is to
modulate the functions of p53. The N terminus of MDM2 interacts with p53, whereas the …

Background The murine double minute 2 (MDM2) is an oncogene and a negative regulator
of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human …