The total GSH depletion observed in the substantia nigra (SN) appears to be responsible for
subsequent oxidative stress (OS), mitochondrial dysfunction, and dopaminergic cell loss in …

Parkinson's disease (PD) is characterized by the selective loss of dopaminergic nigrostriatal
neurons, which leads to disabling motor disturbances. Sulforaphane (SFN), found in …

Recent evidence has focused attention on the role of oxidative stress in various acute and
chronic neurodegenerative diseases. Particularly, a decrease in the level of the powerful …

Oxidative stress is believed to play a key role in the degeneration of dopaminergic neurons
in the substantia nigra (SN) of Parkinson's disease (PD) patients. An important biochemical …

Nigral cell death in Parkinson's disease (PD) may involve oxidative stress and mitochondrial
dysfunction initiated by a decrease in reduced glutathione (GSH) levels in substantia nigra …

Sulfuretin, a potent anti-oxidant, has been thought to provide health benefits by decreasing
the risk of oxidative stress-related diseases. In this study, we investigated the mechanisms of …

To date, glutathione (GSH) depletion is the earliest biochemical alteration shown in brains of
Parkinson's disease patients, but the role of GSH in dopamine cell survival is debated. In this …

The endogenous neurotoxin, 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline
(salsolinol), has been considered a potential neurotoxin in the etiology of Parkinson's …

Adverse reactions to antipsychotic drugs (APs) have been attributed to oxidative stress.
Sulforaphane (SF) is a potent antioxidant that protects against dopaminergic cell death. We …

Parkinson's disease (PD) is a progressive neurodegenerative disorder with selective loss of
dopaminergic neurons in the substantia nigra. Evidence suggests that oxidative stress is …