Abstract Abstract 2540 Poster Board II-517 Platelets collected from donors have very limited
shelf life and are increasingly needed for transfusions. In contrast to donor dependent cord …

Background The production of human platelets from embryonic stem cells in a defined
culture system is a prerequisite for the generation of platelets for therapeutic use. As an …

Platelets, the chief effector of hemostasis, are small anucleate blood cells generated from
megakaryocytes (MKs), and the defects in platelet production or function lead to a variety of …

Megakaryocytes (MKs) are specialized precursor cells committed to producing and
proliferating platelets. In a cytoskeletal-driven process, mature MKs generate platelets by …

Objectives Ex vivo engineered production of megakaryocytes (MKs) and platelets (PLTs)
from human pluripotent stem cells is an alternative approach to solve shortage of donor …

Platelets are essential for hemostatic plug formation and thrombosis. The mechanisms of
megakaryocyte (MK) differentiation and subsequent platelet production from stem cells …

Platelets play an essential role in hemostasis and atherothrombosis. Owing to their short
storage time, there is constant demand for this life-saving blood component. In this study, we …

The process of hemostasis and blood coagulation relies heavily on a sufficient supply of
platelets (PLTs, also known as thrombocytes) within a person's bloodstream. Platelet …

Human embryonic stem cells (hESCs) represent a potential source of blood cells for
transfusion therapies and a promising tool for studying the ontogeny of hematopoiesis …

Megakaryocytes (MKs) are rare hematopoietic cells in the adult bone marrow and produce
platelets that are critical to vascular hemostasis and wound healing. Ex vivo generation of …