[HTML][HTML] Glioblastoma in elderly patients: current management and future perspectives

G Minniti, G Lombardi, S Paolini - Cancers, 2019 - mdpi.com
The incidence of glioblastoma (GBM) in the elderly population is slowly increasing in
Western countries. Current management includes surgery, radiation therapy (RT) and …

Optimal management of elderly patients with glioblastoma

N Laperriere, M Weller, R Stupp, JR Perry… - Cancer treatment …, 2013 - Elsevier
Median age at diagnosis in patients with glioblastoma (GB) is slowly increasing with an
aging population in Western countries, and was 64years in 2006. The number of patients …

Phase II study of short-course radiotherapy plus concomitant and adjuvant temozolomide in elderly patients with glioblastoma

G Minniti, G Lanzetta, C Scaringi, P Caporello… - International Journal of …, 2012 - Elsevier
PURPOSE: Radiotherapy (RT) and chemotherapy may prolong survival in older patients
(age≥ 70 years) with glioblastoma multiforme (GBM), although the survival benefits remain …

Glioblastoma in elderly patients: safety and efficacy of adjuvant radiotherapy with concomitant temozolomide

F Fiorica, M Berretta, C Colosimo, A Stefanelli… - Archives of gerontology …, 2010 - Elsevier
The aim of this study was to evaluate the impact of radiotherapy plus concomitant and
adjuvant temozolomide (TMZ), in terms of feasibility and activity, in elderly patients with …

Glioblastoma treatment in the elderly

M Okada, K Miyake, T Tamiya - Neurologia medico-chirurgica, 2017 - jstage.jst.go.jp
Although current treatment advances prolong patient survival, treatment for glioblastoma
(GBM) in the elderly has become an emerging issue. The definition of “elderly” differs across …

Treatment of elderly patients with glioblastoma: a systematic evidence-based analysis

OJ Zarnett, A Sahgal, J Gosio, J Perry… - JAMA …, 2015 - jamanetwork.com
Importance Despite improvements in survival with aggressive chemoradiation, outcomes for
patients diagnosed as having glioblastoma multiforme (GBM) remain poor. Survival is further …

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients

G Minniti, V De Sanctis, R Muni, F Filippone… - Journal of neuro …, 2008 - Springer
Objectives The optimal treatment for elderly patients (age> 70 years) with glioblastoma
remains controversial. We conducted a prospective trial in 32 consecutive elderly patients …

Treatment and outcomes for glioblastoma in elderly compared with non-elderly patients: a population-based study

ER Morgan, A Norman, K Laing, MD Seal - Current Oncology, 2017 - mdpi.com
Purpose: Elderly patients make up a large percentage of the individuals newly diagnosed
with glioblastoma (gbm), but they face particular challenges in tolerating standard therapy …

Radiotherapy and concomitant temozolomide may improve survival of elderly patients with glioblastoma

CA Barker, M Chang, JF Chou, Z Zhang, K Beal… - Journal of neuro …, 2012 - Springer
Survival of elderly patients with glioblastoma (GBM) is poor, but improves with tumor
resection and radiotherapy (RT). Concurrent temozolomide (TMZ) chemotherapy during RT …

Treatment options and outcomes for glioblastoma in the elderly patient

ND Arvold, DA Reardon - Clinical interventions in aging, 2014 - Taylor & Francis
Age remains the most powerful prognostic factor among glioblastoma (GBM) patients. Half of
all patients with GBM are aged 65 years or older at the time of diagnosis, and the incidence …