The melanocortins, a family of peptides produced from the post-translational processing of
pro-opiomelanocortin (POMC), regulate ingestive behavior and energy expenditure. Loss of …

Accumulating evidence indicates that the central melanocortin (MC) system plays a key role
in the regulation of food intake and energy balance. This evidence includes findings that …

The importance of the central melanocortin system in the regulation of energy balance is
highlighted by studies in transgenic animals and humans with defects in this system. Mice …

Identifying the role of the melanocortin system in regulating energy homeostasis has relied
on both genetic and pharmacological studies. The key findings included 1) that the coat …

Melanocortin peptides, derived from POMC (pro-opiomelanocortin) are produced in the ARH
(arcuate nucleus of the hypothalamus) neurons and the neurons in the commissural NTS …

The melanocortin peptides derived from pro-opiomelanocortin (POMC) were originally
understood in terms of the biological actions of α-melanocyte-stimulating hormone (α-MSH) …

The peptide products of the pro-opiomelanocortin (POMC) gene have established roles in
the control of physiological processes as diverse as adrenal steroidogenesis, skin …

POMC (pro-opiomelanocortin) is a complex polypeptide precursor which is cleaved into
smaller biologically active peptides such as the melanocortins, α-, β-and γ-melanocyte …

Energy balance is a highly regulated, complex process which is modulated by central and
peripheral systems. Dysregulation of energy homeostasis can result in metabolic disorders …

Proopiomelanocortin (POMC) is expressed in the arcuate nucleus of the hypothalamus
(ARC) and the commissural nucleus of the solitary tract (cNTS). Post‐translational …