Farnesyltransferase (FTase) is a key enzyme that catalyzes the farnesylation of Ras protein.
It is used to bind RAS protein to plasma membrane to complete signal transduction. Ras has …

Highlights•Structures and therapeutic importance of FTase and GGTase-1 are briefly
outlined.•Available inhibitors of FTase and GGTase-1 are systematically …

Inhibition of Farnesyltransferase (FTase) has been thoroughly investigated as a strategy to
discover novel anticancer drugs because the oncoprotein Ras, requires farnesylation for its …

Cancer is a serious disease characterized by the uncontrolled growth division of cells, and
nowadays it remains a significant challenge for the medical field. Malaria is an infectious …

New targets for drug discovery have been identified rapidly as a result of the many recent
and rapid advances in the understanding of signal transduction pathways that contribute to …

As one of the world's five terminally ills, tumours can cause important genetic dysfunction.
However, some current medicines for tumours usually have strong toxic side effects and are …

Abstract Background Farnesyltransferase inhibitors (FTIs) are anticancer agents developed
to inhibit Ras oncoprotein activities. FTIs of different chemical structure act via a conserved …

Farnesyltransferase (FTase) is a zinc enzyme that has been the subject of particular
attention in anti-cancer research. This enzyme promotes the addition of a farnesyl group …

Nowadays, molecular targeted cancer therapies represent the core of translational research.
Protein prenylation [covalent binding of either a farnesyl (15-C) or a geranylgeranyl (20-C) …

In this study, 22 novel hFTase inhibitors containing 18 scaffolds were identified with IC50
values ranging from 0.0119 to 13.35 μM by structure-based virtual screening, and …