We investigated the expression of transforming growth factor-β1 (TGF-β1) and connective
tissue growth factor (CTGF) in the liver tissue of infants with congenital biliary atresia and …

BACKGROUND/PURPOSE: Connective tissue growth factor (CTGF) has been implicated in
the pathogenesis of hepatic fibrosis and is elevated in the serum of children with biliary …

Although several liver diseases of childhood, particularly biliary atresia (BA) and cystic
fibrosis (CF) liver disease (CFLD) are characterized by hepatic fibrosis, the pathogenesis of …

Connective tissue growth factor (CTGF) is a newly described protein that stimulates
transforming growth factor-β1 (TGF-β1). We evaluated the expression of CTGF mRNA in …

BACKGROUND/PURPOSE: Transforming growth factor-beta (TGF-β) 1 and 2 and their
receptors TβR-I, TβR-II, and TβR-III are powerful profibrogenic mediators in the body. Their …

Objective: Connective tissue growth factor (CTGF) has been proposed to play a key role in
the pathogenesis of hepatic fibrosis in biliary atresia (BA). The aim of the present study was …

Background/Aims: Biliary atresia and paucity of intrahepatic bile ducts are the main causes
of neonatal cholestasis leading to hepatic fibrosis. Fibrotic evolution is slow in paucity of bile …

Purpose: Biliary atresia (BA) is the most common indication of liver transplantation in
children. Pathogenesis of hepatic fibrosis, which is a prominent feature of BA, remains …

We investigated the expression of transforming growth factor-alpha (TGF-α) and its receptor
during human liver development and maturation, using immunohistochemistry. In the fetal …

Abstract Background and Aim: Biliary atresia (BA) is a serious liver disease in children.
Since transforming growth factor-β1 (TGF-β1) and epidermal growth factor (EGF) are …