[HTML][HTML] The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
Malaria treatment performance is potentially influenced by pharmacogenetic factors. This
study reports an association study between the ABCB1 c. 3435C> T, CYP3A4* 1B (g.-392A> …
study reports an association study between the ABCB1 c. 3435C> T, CYP3A4* 1B (g.-392A> …
MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy
K Vos, CL Sciuto, R Piedade, M Ashton… - …, 2017 - Future Medicine
Aim: To investigate the potential involvement of the hepatic ATP-binding cassette
transporters MRP2 and MDR1 in the disposition of lumefantrine (LUM) among patients with …
transporters MRP2 and MDR1 in the disposition of lumefantrine (LUM) among patients with …
[HTML][HTML] Association between ABCB1 Polymorphisms and Artesunate–Mefloquine Treatment Responses of Patients with Falciparum Malaria on the Thailand …
K Boonprasert, N Kosa, P Muhamad… - The American Journal …, 2021 - ncbi.nlm.nih.gov
A decrease in the clinical efficacy of a 3-day artesunate–mefloquine combination treatment
was reported in the areas of multidrug-resistant Plasmodium falciparum along the Thailand …
was reported in the areas of multidrug-resistant Plasmodium falciparum along the Thailand …
[HTML][HTML] Therapeutic efficacy of generic artemether–lumefantrine in the treatment of uncomplicated malaria in Ghana: assessing anti-malarial efficacy amidst …
Background Despite efforts made to reduce morbidity and mortality associated with malaria,
especially in sub-Saharan Africa, malaria continues to be a public health concern that …
especially in sub-Saharan Africa, malaria continues to be a public health concern that …
Effect of CYP3A5*3 genotypes on lumefantrine plasma concentrations among malaria-HIV-infected women
Aim: We aimed to assess the effect of a functional polymorphism of CYP3A5 on lumefantrine
pharmacokinetics. Patients & methods: Sixty-nine women diagnosed with malaria received …
pharmacokinetics. Patients & methods: Sixty-nine women diagnosed with malaria received …
[HTML][HTML] Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate‐amodiaquine treatment of uncomplicated Plasmodium …
L Pernaute-Lau, U Morris, M Msellem, A Mårtensson… - Malaria Journal, 2021 - Springer
Background The anti-malarial drug, amodiaquine, a commonly used, long-acting partner
drug in artemisinin-based combination therapy, is metabolized to active desethyl …
drug in artemisinin-based combination therapy, is metabolized to active desethyl …
[HTML][HTML] Temporal trends of molecular markers associated with artemether-lumefantrine tolerance/resistance in Bagamoyo district, Tanzania
Background Development and spread of Plasmodium falciparum resistance to artemisinin-
based combination therapy (ACT) constitutes a major threat to recent global malaria control …
based combination therapy (ACT) constitutes a major threat to recent global malaria control …
Effect of Single Nucleotide Polymorphisms in Cytochrome P450 Isoenzyme and N-Acetyltransferase 2 Genes on the Metabolism of Artemisinin-Based Combination …
EM Staehli Hodel, C Csajka, F Ariey… - Antimicrobial agents …, 2013 - Am Soc Microbiol
The pharmacogenetics of antimalarial agents are poorly known, although the application of
pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic …
pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic …
[HTML][HTML] Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women
RF Mutagonda, AAR Kamuhabwa, OMS Minzi… - Malaria journal, 2017 - Springer
Background Pregnancy has considerable effects on the pharmacokinetic properties of drugs
used to treat uncomplicated Plasmodium falciparum malaria. The role of pharmacogenetic …
used to treat uncomplicated Plasmodium falciparum malaria. The role of pharmacogenetic …
Plasmodium falciparum Polymorphisms Associated with Ex Vivo Drug Susceptibility and Clinical Effectiveness of Artemisinin-Based Combination Therapies in Benin
S Dahlström, A Aubouy, O Maïga-Ascofaré… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Artemisinin-based combination therapies (ACTs) are the main option to treat malaria, and
their efficacy and susceptibility must be closely monitored to avoid resistance. We assessed …
their efficacy and susceptibility must be closely monitored to avoid resistance. We assessed …