We investigated whether older adults without subjective memory complaints, but who
present with cognitive decline in the laboratory, demonstrate atrophy in medial temporal …

Introduction Loss of entorhinal cortex (EC) layer II neurons represents the earliest
Alzheimer's disease (AD) lesion in the brain. Research suggests differing functional roles …

Atrophy in the medial temporal lobe is generally considered to be highly associated with age-
related memory decline. Volume loss in the hippocampus and entorhinal cortex has …

Recent functional imaging studies have proposed that the human entorhinal cortex (ERC) is
subdivided into functionally distinct anterolateral (alERC) and posteromedial (pmERC) …

The entorhinal cortex is the site of some of the earliest pathological changes in Alzheimer's
disease, including neuronal, synaptic and volumetric loss. Specifically, the lateral entorhinal …

Our goal was to ascertain, among normal elderly and individuals with mild cognitive
impairment, which temporal lobe neocortical regions predicted decline to dementia of the …

Entorhinal cortex (ERC) volume in adults with mild cognitive impairment has been shown to
predict prodromal Alzheimer's disease (AD). Likewise, neuronal loss in ERC has been …

Background Early pathological involvement of specific medial temporal lobe areas is
characteristic for Alzheimer's disease (AD). Objective To determine the extent of regional …

Studying the distribution and chronological sequence of brain morphological changes that
occur in normal aging is crucial for understanding the mechanisms underlying these …

Background: In Alzheimer's disease, neurodegenerative atrophy progresses from the
entorhinal cortex (ERC) to the hippocampus (HP), limbic system and neocortex. The …