Cell systems bioelectricity: how different intercellular gap junctions could regionalize a multicellular aggregate
Simple Summary Electric potential patterns across tissues are instructive for development,
regeneration, and tumorigenesis because they can influence transcription, migration, and …
regeneration, and tumorigenesis because they can influence transcription, migration, and …
Community effects allow bioelectrical reprogramming of cell membrane potentials in multicellular aggregates: Model simulations
Bioelectrical patterns are established by spatiotemporal correlations of cell membrane
potentials at the multicellular level, being crucial to development, regeneration, and …
potentials at the multicellular level, being crucial to development, regeneration, and …
[PDF][PDF] Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer
M Levin - Cell, 2021 - cell.com
How are individual cell behaviors coordinated toward invariant large-scale anatomical
outcomes in development and regeneration despite unpredictable perturbations …
outcomes in development and regeneration despite unpredictable perturbations …
From non-excitable single-cell to multicellular bioelectrical states supported by ion channels and gap junction proteins: Electrical potentials as distributed controllers
Endogenous bioelectric patterns within tissues are an important driver of morphogenesis
and a tractable component of a number of disease states. Developing system-level …
and a tractable component of a number of disease states. Developing system-level …
Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo
M Levin - Molecular biology of the cell, 2014 - Am Soc Cell Biol
In addition to biochemical gradients and transcriptional networks, cell behavior is regulated
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …
Bioelectrical signals and ion channels in the modeling of multicellular patterns and cancer biophysics
Bioelectrical signals and ion channels are central to spatial patterns in cell ensembles, a
problem of fundamental interest in positional information and cancer processes. We propose …
problem of fundamental interest in positional information and cancer processes. We propose …
Epithelial tissue geometry directs emergence of bioelectric field and pattern of proliferation
Patterns of proliferation are templated by both gradients of mechanical stress as well as by
gradients in membrane voltage (Vm), which is defined as the electric potential difference …
gradients in membrane voltage (Vm), which is defined as the electric potential difference …
Electrical dimensions in cell science
CD McCaig, B Song, AM Rajnicek - Journal of cell science, 2009 - journals.biologists.com
Cells undergo a variety of physiological processes, including division, migration and
differentiation, under the influence of endogenous electrical cues, which are generated …
differentiation, under the influence of endogenous electrical cues, which are generated …
Endogenous voltage gradients as mediators of cell-cell communication: strategies for investigating bioelectrical signals during pattern formation
Alongside the well-known chemical modes of cell-cell communication, we find an important
and powerful system of bioelectrical signaling: changes in the resting voltage potential (V …
and powerful system of bioelectrical signaling: changes in the resting voltage potential (V …
Bioelectricity of non-excitable cells and multicellular pattern memories: Biophysical modeling
Cells must coordinate their individual activities toward multicellular goals, which requires
efficient information processing mechanisms. Bioelectrical signals encode instructive rules …
efficient information processing mechanisms. Bioelectrical signals encode instructive rules …