Background Superantigens are indispensable virulence factors for Staphylococcus aureus
in disease causation. Superantigens stimulate massive immune cell activation, leading to …

Staphylococcus aureus infective endocarditis (IE) is a fast-progressing and tissue-
destructive infection of the cardiac endothelium. The superantigens (SAgs) toxic shock …

Infections with multidrug resistant (MDR) bacteria represent a major challenge for public
health. Methicillin resistant S. aureus (MRSA) is one of the leading causes of hospital and …

Staphylococcus aureus produces superantigens (SAgs) that bind and cross-link T cells and
APCs, leading to activation and proliferation of immune cells. SAgs bind to variable regions …

Background Bacterial superantigens are virulence factors that cause toxic shock syndrome.
Here, the genome-wide, temporal response of mice to lethal intranasal staphylococcal …

Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …

Staphylococcal enterotoxins are a wide family of bacterial exotoxins with the capacity to
activate as much as 20% of the host T cells, which is why they were called superantigens …

Staphylococcal enterotoxin B (SEB) of Staphylococcus aureus, and related superantigenic
toxins produced by myriad microbes, are potent stimulators of the immune system causing a …

Staphylococcal exotoxins, staphylococcal enterotoxins AE (SEA-SEE), and toxic shock
syndrome toxin-1 (TSST-1) are potent activators of the immune system and cause a variety …

The species Staphylococcus aureus harbors 19 superantigen gene loci, six of which are
located in the enterotoxin gene cluster (egc). Although these egc superantigens are far more …