Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …

Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the US and
UK. Recent studies implied that APAP-induced injury is partially mediated by interleukin-1β …

Hepatocyte death results in a sterile inflammatory response that amplifies the initial insult
and increases overall tissue injury. One important example of this type of injury is …

Acetaminophen (APAP) overdose leads to liver injury. NLRP3 inflammasome is a key player
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …

Acetaminophen (APAP) overdose can result in serious liver injury and potentially death.
Toxicity is dependent on metabolism of APAP to a reactive metabolite initiating a cascade of …

Acetaminophen (APAP) hepatotoxicity because of overdose is the most frequent cause of
acute liver failure in the western world. Metabolic activation of APAP and protein adduct …

The metabolic intermediate of acetaminophen (APAP) can cause severe hepatocyte
necrosis, which triggers aberrant immune activation of liver non-parenchymal cells (NPC) …

Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury
after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such …

Neutrophils are recruited into the liver after acetaminophen (AAP) overdose but the
pathophysiological relevance of this acute inflammatory response remains unclear. To …

Neutrophils and macrophages infiltrate after acetaminophen (APAP)‐induced liver injury
starts to develop. However, their precise roles still remain elusive. In untreated and control …