Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure
BL Woolbright, H Jaeschke - Journal of hepatology, 2017 - Elsevier
Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …
overdose is the number one cause of acute liver failure and remains a major problem in …
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury
CD Williams, DJ Antoine, PJ Shaw, C Benson… - Toxicology and applied …, 2011 - Elsevier
Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the US and
UK. Recent studies implied that APAP-induced injury is partially mediated by interleukin-1β …
UK. Recent studies implied that APAP-induced injury is partially mediated by interleukin-1β …
Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
AB Imaeda, A Watanabe, MA Sohail… - The Journal of …, 2009 - Am Soc Clin Investig
Hepatocyte death results in a sterile inflammatory response that amplifies the initial insult
and increases overall tissue injury. One important example of this type of injury is …
and increases overall tissue injury. One important example of this type of injury is …
Hepatoprotective effect of allicin against acetaminophen‐induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration
Acetaminophen (APAP) overdose leads to liver injury. NLRP3 inflammasome is a key player
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …
Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury
CD Williams, A Farhood, H Jaeschke - Toxicology and applied …, 2010 - Elsevier
Acetaminophen (APAP) overdose can result in serious liver injury and potentially death.
Toxicity is dependent on metabolism of APAP to a reactive metabolite initiating a cascade of …
Toxicity is dependent on metabolism of APAP to a reactive metabolite initiating a cascade of …
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity
H Jaeschke, CD Williams, A Ramachandran… - Liver …, 2012 - Wiley Online Library
Acetaminophen (APAP) hepatotoxicity because of overdose is the most frequent cause of
acute liver failure in the western world. Metabolic activation of APAP and protein adduct …
acute liver failure in the western world. Metabolic activation of APAP and protein adduct …
Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity
C Zhang, J Feng, J Du, Z Zhuo, S Yang… - Cellular & Molecular …, 2018 - nature.com
The metabolic intermediate of acetaminophen (APAP) can cause severe hepatocyte
necrosis, which triggers aberrant immune activation of liver non-parenchymal cells (NPC) …
necrosis, which triggers aberrant immune activation of liver non-parenchymal cells (NPC) …
Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity
H Jaeschke, A Ramachandran - Food and chemical toxicology, 2020 - Elsevier
Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury
after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such …
after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such …
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity
C Cover, J Liu, A Farhood, E Malle, MP Waalkes… - Toxicology and applied …, 2006 - Elsevier
Neutrophils are recruited into the liver after acetaminophen (AAP) overdose but the
pathophysiological relevance of this acute inflammatory response remains unclear. To …
pathophysiological relevance of this acute inflammatory response remains unclear. To …
Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen‐induced acute liver injury
Neutrophils and macrophages infiltrate after acetaminophen (APAP)‐induced liver injury
starts to develop. However, their precise roles still remain elusive. In untreated and control …
starts to develop. However, their precise roles still remain elusive. In untreated and control …