Background A pharmacovigilance database of real-world adverse drug reaction (ADR)
reports is helpful for characterising adverse events and identifying new signals after drug …

Objective To describe hepatotoxicity due to amiodarone and dronedarone from the DILIN
and the US FDA's surveillance database. Methods Hepatotoxicity due to amiodarone and …

Abstract Background/Aim The number of patients receiving amiodarone will increase in
future years. As clinically significant hepatotoxicity associated with oral amiodarone is …

Risk factors and underlying mechanisms for liver injury associated with amiodarone remain
elusive. This study aimed to investigate the drug-related covariates for acute liver injury by …

DISCUSSION Despite its ubiquitous and clinically important role as a central antiarrhythmic
agent, amiodarone's significant toxicity and side effect profile represent a considerable …

Drug and Chemical Toxicology and males showed a higher incidence of hepatotoxicity than
females in patients receiving iv amiodarone treatment (Huang et al., 2009). Hepatic toxicity …

Background Spontaneous reports of acute liver injuries (ALI) in patients taking dronedarone
triggered an EMA alert in 2011. This study aimed to assess the risk of ALI for class III …

Background Intravenous (IV) amiodarone may be associated with liver injury that may
necessitate drug discontinuation. The prediction of amiodarone induced liver injury (AILI) …

Purpose To determine the incidence, demographic profile, background of reporters,
causative agents, severity and clinical outcomes of hepatic adverse drug reaction (ADR) …

Discussion Amiodarone is a commonly used antiarrhythmic. It is associated with
extracardiac side effects, including asymptomatic hepatic dysfunction in 15–40% of patients …