Establishment of a mouse model for amiodarone‐induced liver injury and analyses of its hepatotoxic mechanism

S Takai, S Oda, K Tsuneyama, T Fukami… - Journal of Applied …, 2016 - Wiley Online Library
Drug‐induced liver injury (DILI) is the most frequent cause of post‐marketing warnings and
withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans …

A comparison of three different sources of data in assessing the frequencies of adverse reactions to amiodarone

YK Loke, S Derry, JK Aronson - British journal of clinical …, 2004 - Wiley Online Library
Aims To compare the frequencies of adverse drug reactions (ADRs) to amiodarone from
three separate datasets:(i) a meta‐analysis of clinical trials,(ii) spontaneous reports …

Drug induced hepatotoxicity: data from the Serbian pharmacovigilance database

M Petronijevic, K Ilic, A Suzuki - … and drug safety, 2011 - Wiley Online Library
Purpose The main aim of this study was to determine the most frequently reported drugs to
the Serbian Pharmacovigilance Database (SPD) with suspected induced hepatotoxicity …

Amiodarone hepatotoxicity: prevalence and clinicopathologic correlations among 104 patients

JH Lewis, RC Ranard, A Caruso, LK Jackson… - Hepatology, 1989 - journals.lww.com
The prevalence of apparent amiodarone-related hepatic injury in 104 patients followed
prospectively is compared to that reported in the literature. Asymptomatic elevation of serum …

Postmarketing surveillance of drug-induced liver injury

SC Jones, C Kortepeter, AD Brinker - Drug-Induced Liver Toxicity, 2018 - Springer
Background Most clinical trials that support approval are not adequately powered to detect
rare adverse reactions (eg, drug-induced liver injury, Stevens–Johnson syndrome, and …

Acute amiodarone liver toxicity likely due to ischemic hepatitis.

N Gluck, M Fried, R Porat - Sat, 2011 - ima.org.il
Background: Hepatotoxicity due to intravenous amiodarone (HIVAD) is a rare side effect with
a distinct pattern of enzyme disturbances compared to liver damage from oral amiodarone …

[HTML][HTML] Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: a case report

H Oikawa, C Maesawa, R Sato, K Oikawa… - World Journal of …, 2005 - ncbi.nlm.nih.gov
The anti-arrhythmic agent amiodarone (AD) is associated with numerous adverse effects,
but serious liver disease is rare. The improved safety of administration of daily low doses of …

Acute hepatotoxicity of intravenous amiodarone: case report and review of the literature

CC Chen, CC Wu - American journal of therapeutics, 2016 - journals.lww.com
Amiodarone is a class III antiarrhythmic drug widely used for the treatment of both
supraventricular and ventricular arrhythmias in intensive care unit. Hepatotoxicity of …

Amiodarone liver toxicity about two cases and review of literature

J Iba-Ba, M Tilea, JL Balligand… - La Revue de …, 2004 - pubmed.ncbi.nlm.nih.gov
Introduction Amiodarone can induced hepatic dysfunction. Observations We describe two
patients who developed hepatotoxicity presenting suggestive histological features. The …

[HTML][HTML] Acute fulminant hepatic failure and renal failure induced by oral amiodarone: A case report and literature review

N Campbell, K Agarwal, M Alidoost, JA Miskoff… - Cureus, 2020 - ncbi.nlm.nih.gov
Amiodarone is a class III antiarrhythmic agent that inhibits adrenergic stimulation by blocking
alpha and beta receptors. It prolongs action potential and refractory period in myocardial …