The fungal pathogen, Cryptococcus neoformans, has been shown to undergo replicative
aging. Old cells are characterized by advanced generational age and phenotypic changes …

Highlights•Aging is evolutionarily conserved among organisms from all orders.•Replicative
and chronological aging are two distinct forms of aging.•Nutrition and genetic background …

Cryptococcus neoformans (Cn) is a deadly fungal pathogen responsible for~ 180,000
deaths per year and despite effective antifungals, treatment failure and resistance to …

Replicative aging is an underexplored field of research in medical mycology. Cryptococcus
neoformans (Cn) and Candida glabrata (Cg) are dreaded fungal pathogens that cause fatal …

The fungal pathogen Cryptococcus neoformans has several virulence factors, among which
the most important is a polysaccharide capsule. The size of the capsule is variable and can …

Cryptococcus neoformans successfully replicates in low glucose in infected patients. In the
serotype A strain, H99, growth in this condition prolongs lifespan regulated by SIR2, and can …

Does cell age matter in virulence? The emergence of persister cells during chronic
infections is critical for persistence of infection, but little is known how this occurs. Here, we …

Cryptococcus neoformans is a facultative intracellular fungal pathogen. Ten-generation-old
(10GEN) C. neoformans cells are more resistant to phagocytosis and killing by …

Fungal infections are a global concern and the evolution of intrinsic resistance to current
antifungals presents an alarming problem. For Cryptococcus neoformans, a human fungal …

Cryptococcus neoformans, similar to other eukaryotes, undergoes replicative aging.
Replicative life spans have been determined for clinical C. neoformans strains, and although …