Intestinal permeability is a key biopharmaceutical variable in pharmaceutical research and
development, and regulatory assessment. In situ rat models are often used to predict the …

Intestinal drug permeability has been recognized as a critical determinant of the fraction
dose absorbed, with direct influence on bioavailability, bioequivalence and biowaiver. The …

The aim of the present work was to study the intestinal permeabilities (Peff) of five model
drugs: furosemide, piroxicam, naproxen, ranitidine and amoxicillin in the in situ intestinal …

The in vitro permeability of a series of both hydrophilic and lipophilic compounds, as defined
by the octanol/water partition coefficient, was measured in four segments of rabbit, monkey …

Currently, the screening of new drug candidates for intestinal permeation is typically based
on in vitro models which give no information regarding regional differences along the gut …

Both the development and regulation of pharmaceutical dosage forms have undergone
significant improvements and development over the past 25 years, due primarily to the …

This review focuses on intestinal permeability measurements in humans and various
aspects of in‐vivo transport mechanisms. In addition, comparisons of human data with …

Experimental models of permeability in animals, excised tissues, cell monolayers, and
artificial membranes are important during drug discovery and development as permeability …

Intestinal drug permeability is position dependent and pertains to a specific point along the
intestinal membrane, and the resulted segmental-dependent permeability phenomenon has …

Purpose. Our main aim is to determine the effective intestinal permeability (P eff) in the rat
jejunum in situ for 10 compounds with different absorption mechanisms and a broad range …