[HTML][HTML] A Novel C Type CpG Oligodeoxynucleotide Exhibits Immunostimulatory Activity In Vitro and Enhances Antitumor Effect In Vivo
T Li, J Wu, S Zhu, G Zang, S Li, X Lv, W Yue… - Frontiers in …, 2020 - frontiersin.org
Background C type CpG oligodeoxynucleotides (CpG-C ODNs), possessing the features of
both A type and B type CpG ODNs, exert a variety of immunostimulatory activities and have …
both A type and B type CpG ODNs, exert a variety of immunostimulatory activities and have …
[HTML][HTML] Immunostimulatory and anti-neoplasm effects of a novel palindrome CpG oligodeoxynucleotide in mice
H Du, L Dong, B Zhao, J Fu, Q Wang, F Chen… - Acta Pharmacologica …, 2012 - nature.com
Aim: DNAs containing unmethylated CpG motifs can stimulate innate and adaptive immunity.
The aim of this study was to investigate the immunostimulatory and anti-neoplasm effects of …
The aim of this study was to investigate the immunostimulatory and anti-neoplasm effects of …
Cancer immunotherapeutic effects of novel CpG ODN in murine tumor model
HC Cho, BH Kim, K Kim, JY Park, JH Chang… - International …, 2008 - Elsevier
While CpG oligodeoxynucleotides (ODN) are excellent candidates for cancer
immunotherapeutics, the numbers of usable CpG ODNs are limited in current clinical …
immunotherapeutics, the numbers of usable CpG ODNs are limited in current clinical …
CpG oligodeoxynucleotide developed to activate primate immune responses promotes antitumoral effects in combination with a neoantigen-based mRNA cancer …
Q Li, J Ren, W Liu, G Jiang, R Hu - Drug Design, Development and …, 2021 - Taylor & Francis
Purpose The purpose of our research was to identify and evaluate synthetic
phosphorothioate-modified CPG oligodeoxynucleotides (CPG-ODNs) activating innate and …
phosphorothioate-modified CPG oligodeoxynucleotides (CPG-ODNs) activating innate and …
CpG oligodeoxynucleotides with double stem-loops show strong immunostimulatory activity
L Yang, X Wu, M Wan, Y Yu, Y Yu, L Wang - International …, 2013 - Elsevier
Based on the current understanding of TLR9 recognition of CpG ODN, we have tried to
design a series of CpG ODNs that display double stem-loops when being analyzed for their …
design a series of CpG ODNs that display double stem-loops when being analyzed for their …
Class C CpG oligodeoxynucleotides as a single agent and in combination with radiotherapy efficiently delayed growth of subcutaneous B16F1 tumors
P Cerkovnik, B Jezersek Novakovic, V Stegel… - Innate …, 2009 - journals.sagepub.com
Until now, the anti-tumor efficacy of synthetic oligodeoxynucleotides containing CpG motifs
(CpG ODNs) has been reported in a number of preventive and therapeutic tumor models …
(CpG ODNs) has been reported in a number of preventive and therapeutic tumor models …
Structure-efficacy relationships of immunostimulatory activity of CpG-containing oligodeoxynucleotides on mouse spleen cells
HY Du, SY Xia, H Song, N Li, M Shang, J Zou… - Acta Pharmacologica …, 2007 - nature.com
Aim: To study the relationship between primary structures of oligodeoxynucleo-tides (ODN)
containing unmethylated deoxycytidyl-deoxyguanosine (CpG) dinucleotide motifs and their …
containing unmethylated deoxycytidyl-deoxyguanosine (CpG) dinucleotide motifs and their …
CpG oligodeoxynucleotide 1826 enhances the Lewis lung cancer response to radiotherapy in murine tumor
S Yuan, T Qiao, W Chen - Cancer Biotherapy & …, 2011 - liebertpub.com
CpG oligodeoxynucleotides (ODNs) are synthetic DNA sequences containing unmethylated
cytosine–guanine motifs with potent immune modulatory effects. Via Toll-like receptor 9 …
cytosine–guanine motifs with potent immune modulatory effects. Via Toll-like receptor 9 …
[HTML][HTML] Discrepant antitumor efficacies of three CpG oligodeoxynucleotide classes in monotherapy and co-therapy with PD-1 blockade
T Li, C Hua, W Yue, J Wu, X Lv, Q Wei, S Zhu… - Pharmacological …, 2020 - Elsevier
Abstract Unmethylated CpG oligodeoxynucleotides (ODNs) activate plasmacytoid dendritic
cells (pDCs) and B cells to induce humoral and cellular immunity, and are under …
cells (pDCs) and B cells to induce humoral and cellular immunity, and are under …
CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways
XF Qi, L Zheng, CS Kim, KJ Lee, DH Kim, DQ Cai… - Molecular …, 2013 - Elsevier
Recent studies have suggested that the anti-cancer activity of CpG-oligodeoxynucleotides
(CpG-ODNs) is owing to their immunomodulatory effects in tumor-bearing host. The purpose …
(CpG-ODNs) is owing to their immunomodulatory effects in tumor-bearing host. The purpose …