Diffuse projections of locus coeruleus (LC) neurons and evidence of synchronous spiking
have long been perceived as features of global neuromodulation. Recent studies …

The locus coeruleus (LC, Lat.“blue spot”) is a heavily pigmented nucleus located in the
dorsal wall of the rostral pons in the lateral floor of the fourth ventricle (Figure 12.1). The LC …

Noradrenergic neurons were first demonstrated in the central nervous system in 1965. The
neurons were clustered in nuclear groups throughout the brainstem and were identified as …

The locus coeruleus (LC) is the major noradrenergic nucleus of the brain, giving rise to
fibres innervating extensive areas throughout the neuraxis. Recent advances in …

The brain stem nucleus locus coeruleus (LC) is thought to modulate cortical excitability by
norepinephrine (NE) release in LC forebrain targets. The effects of LC burst discharge …

Preclinical work has long focused on male animals, though biological sex clearly influences
risk for certain diseases, including many psychiatric disorders. Such disorders are often …

Neuronal responses to sensory stimuli are not only driven by feedforward sensory pathways
but also depend upon intrinsic factors (collectively known as the network state) that include …

The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …

In 1955, noting that the locus coeruleus (LC) had “received only scant attention,” Russell
(1955) reviewed and extended the study of the comparative anatomy of this nucleus …

The release of the neurotransmitter norepinephrine throughout the mammalian brain is
important for modulating attention, arousal, and cognition during many behaviors …