Alkylating and oxidative stresses in smoking and non-smoking patients with COPD: implications for lung carcinogenesis

YM Shih, YJ Chang, MS Cooke, CH Pan, CH Hu… - Free Radical Biology …, 2021 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a disease characterized by chronic
inflammation and irreversible airway obstruction. Cigarette smoking is the predominant risk …

Oxidants and COPD

W MacNee - Current Drug Targets-Inflammation & Allergy, 2005 - ingentaconnect.com
Smoking is the main etiologic factor in chronic obstructive pulmonary disease (COPD).
Cigarette smoke produces an enormous oxidant burden on the lungs, which is exacerbated …

The role of oxidative stress in lung injury induced by cigarette smoke

Z Kluchová, R Tkáčová - Biologia, 2006 - Springer
Oxidative stress is a damaging process resulting from an imbalance between excessive
generation of oxidant compounds and insufficient antioxidant defence mechanisms …

[PDF][PDF] Role of oxidative stress in the pathogenesis of COPD

F Nucera, S Mumby, KR Paudel, V Dharwal… - Minerva …, 2022 - opus.lib.uts.edu.au
Chronic inhalation of cigarette smoke is a prominent cause of chronic obstructive pulmonary
disease (COPD) and provides an important source of exogenous oxidants. In addition …

Oxidative stress in the lung–the essential paradox

LK Rogers, MJ Cismowski - Current opinion in toxicology, 2018 - Elsevier
As eukaryotic life evolved, so too did the need for a source of energy that meets the
requirements of complex organisms. Oxygen provides this vast potential energy source, but …

[HTML][HTML] Associations between urinary biomarkers of oxidative stress and biomarkers of tobacco smoke exposure in smokers

N Sambiagio, A Berthet, P Wild, JJ Sauvain… - Science of The Total …, 2022 - Elsevier
Oxidative stress can contribute to the development of diseases, and may originate from
exposures to toxicants commonly found in air pollution and cigarette smoke such as …

[HTML][HTML] Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD

P Rytilä, T Rehn, H Ilumets, A Rouhos, A Sovijärvi… - Respiratory …, 2006 - Springer
Background Chronic obstructive pulmonary disease (COPD) is associated with increased
oxidative and nitrosative stress. The aim of our study was to assess the importance of these …

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is correlated with 8-hydroxy-2′-deoxyguanosine in humans after exposure to environmental tobacco smoke

HC Chiang, YK Huang, PF Chen, CC Chang… - Science of the Total …, 2012 - Elsevier
Cigarette smoking and exposure to environmental tobacco smoke (ETS) are important risk
factors for many cancers. However, exposure doses have usually not been quantitatively …

[HTML][HTML] Polycyclic aromatic hydrocarbons induced by smoking and air pollution: correlation with oxidative stress in chronic obstructive pulmonary disease patients

I Buculei, ME Dobrin, D Matei, I Onu, C Vicol, IB Cioroiu… - Toxics, 2022 - mdpi.com
Oxidative stress is induced by tobacco smoking and is also associated with exposure to air
pollution, which are two of the most important risk factors for chronic obstructive pulmonary …

Particulate phase cigarette smoke increases MnSOD, NQO1, and CINC-1 in rat lungs

KA Stringer, BM Freed, JS Dunn, S Sayers… - Free Radical Biology …, 2004 - Elsevier
Loss of antioxidant/oxidant homeostasis perpetuates inflammation in the lungs and may
contribute to the development of COPD and lung cancer. Cigarette smoke (CS) is a primary …