Background Hereditary breast and ovarian cancer syndrome (HBOC) is an inherited
disorder with an increased risk of breast cancer (BC) and ovarian cancers (OC). Mutations in …

The increasing application of gene panels for familial cancer susceptibility disorders will
probably lead to an increased proposal of susceptibility gene candidates. Using ERCC2 …

Hereditary Breast and Ovarian Cancer (HBOC) syndrome is a condition in which the risk of
breast and ovarian cancer is higher than in the general population. The prevalent …

Objective Genetic predisposition to ovarian cancer is well documented. With the advent of
next generation sequencing, hereditary panel testing provides an efficient method for …

Background Genetic variants in the excision repair cross-complimentary group 2 (ERCC2)
gene may affect individual susceptibility to cancer by modulating the capability of DNA …

Hereditary breast and ovarian cancer syndrome (HBOC) represents 5–10% of all patients
with breast cancer and is associated with high-risk pathogenic alleles in BRCA1/2 genes …

Aim The reported study was designed to explore associations between the ERCC2-R156R
gene single nucleotide polymorphism (SNP) and the risk of ovarian cancer. Material and …

Simple Summary Hereditary Breast and Ovarian Cancer syndrome (HBOC) is an inherited
trait that predisposes adults to an earlier onset of cancer than the general population. HBOC …

Background Hereditary breast and ovarian cancer (HBOC) is an autosomal dominant
inherited cancer susceptibility disorder. Both BRCA1 and BRCA2 genes are considered as …

Background Genetic screening for pathogenic variants (PVs) in cancer predisposition genes
can affect treatment strategies, risk prediction and preventive measures for patients and …