The membrane-spanning domain (MSD) of the transmembrane subunit (TM) anchors the
envelope glycoprotein (Env) on the lipid bilayer of the host cell membrane and virions. Its …

Background The gp41 subunit of the HIV-1 envelope glycoprotein (Env) has been widely
regarded as a type I transmembrane protein with a single membrane-spanning domain …

Background: HIV-1 infectivity is decreased by specific mutations that alter the hydrophobicity
level in the HIV-1 gp41 loop core. Results: Antibody recognition, disulfide-bond formation …

The membrane-spanning domain (MSD) of the human immunodeficiency virus type 1 (HIV-
1) gp41 glycoprotein is critical for its biological activity. Previous C-terminal truncation …

The fusion core of bovine immunodeficiency virus (BIV) gp40 is proposed to be involved in
membrane fusion. However, no crystal structures are yet available. A predicted protein …

We aimed to make a recombinant human immunodeficiency virus type 1 (HIV-1) envelope
glycoprotein gp140 trimer construct, seek an efficient expression method, and characterize …

Structural and functional studies were performed to assess the membrane actions of
peptides based on HIV-1 glycoprotein 41,000 (gp41). Previous site-directed mutagenesis of …

The cytoplasmic domain of human immunodeficiency virus type 1 (HIV-1) envelope (Env)
transmembrane protein gp41 interacts with the viral matrix MA protein, which facilitates …

Background The sequences of membrane-spanning domains (MSDs) on the gp41 subunit
are highly conserved among many isolates of HIV-1. The GXXXG motif, a potential helix …

In the fight against the human HIV, new targets are being explored, such as the proteins
involved in the process of fusion of the virus with the host cell. Recently, the first generation …