Osteoporosis is one of the most common age‐related progressive bone diseases in elderly
people. Approximately one in three women and one in five men are predisposed to …

ABSTRACT DNA methylation affects expression of associated genes and may contribute to
the missing genetic effects from genome-wide association studies of osteoporosis. To …

Osteoporosis is an age‐related metabolic bone disease. Hence, osteoporotic patients might
suffer from molecular features of accelerated aging, which is generally reflected by specific …

Osteoporosis is characterized by systemic microarchitecture impairment and bone loss,
which ultimately lead to fragility fractures. This disease is most common in older people …

Genetic and environmental determinants of skeletal phenotypes such as bone mineral
density (BMD) may converge through the epigenome, providing a tool to better understand …

Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–
environment interactions, and their role in disease pathogenesis. Blood is an obvious …

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …

Objective To determine genome‐wide methylation profiles of bone from patients with hip
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone …

DNA methylation is an important epigenetic modification that contributes to the lineage
commitment and specific functions of different cell types. In this study, we compared …

Background Observational studies have shown a causal association between dyslipidemia
and osteoporosis, but the genetic causation and complete mechanism of which are …