Background Chlamydia trachomatis is the most common cause of sexually transmitted
infections globally and the leading cause of preventable blindness in the developing world …

Research on the obligate intracellular bacterium Chlamydia trachomatis demands culture in
cell-lines, but the adaptive process behind the in vivo to in vitro transition is not understood …

Chlamydia trachomatis, the etiological agent of sexually transmitted diseases and ocular
infections, remains poorly characterized due to its intractability to experimental …

The development of genetic transformation technology for Chlamydia trachomatis using its
endogenous plasmid has recently been described. Chlamydia muridarum cannot be …

Chlamydia trachomatis is an obligate intracellular pathogen that has been historically
difficult to genetically manipulate. Definitive progress in elucidating the mechanisms that C …

Functional genetic analysis of Chlamydia has been a challenge due to the historical genetic
intractability of Chlamydia, although recent advances in chlamydial genetic manipulation …

Progress in understanding molecular mechanisms contributing to chlamydial pathogenesis
has been greatly facilitated by recent advances in genetic manipulation of C. trachomatis …

Background Pre-genomic and post-genomic studies demonstrate that chlamydiae actively
recombine in vitro and in vivo, although the molecular and cellular biology of this process is …

The native plasmid of both Chlamydia muridarum and Chlamydia trachomatis has been
shown to control virulence and infectivity in mice and in lower primates. We recently …

Chlamydia trachomatis remains one of the few major human pathogens for which there is no
transformation system. C. trachomatis has a unique obligate intracellular developmental …