Cholinergic deficit in Alzheimer's disease: a study based on CSF and autopsy data

KJ Reinikainen, PJ Riekkinen, L Paljärvi… - Neurochemical …, 1988 - Springer
Cholinesterase (ChE) activity was measured as a possible marker of cholinergic
neurotransmission of the brain in CSF of 93 patients with probable Alzheimer's …

Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients

H Henke, W Lang - Brain research, 1983 - Elsevier
Choline acetyltransferase (ChAT) activity and acetylcholinesterase (AChE) staining were
examined in different cortical regions, hippocampal formation and basal forebrain of non …

Choline acetyltransferase immunohistochemistry in brains of Alzheimer's disease patients and controls

T Nagai, PL McGeer, JH Peng, EG McGeer… - Neuroscience …, 1983 - Elsevier
Choline acetyltransferase (ChAT)-containing neuronal structures of the basal forebrain were
studied by ChAT immunohistochemistry in the brains of persons dying with Alzheimer's …

Acetylcholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type

H Soininen, T Halonen… - Acta Neurologica …, 1981 - Wiley Online Library
We have studied, as a possible marker of cholinergic neurons, the acetylcholinesterase
(AChE) activity in cerebrospinal fluid (CSF) of 21 SDA patients and 9 controls of similar age …

Qualitative abnormalities of choline acetyltransferase in Alzheimer type dementia

K Koshimura, T Kato, I Tohyama, S Nakamura… - Journal of the …, 1986 - Elsevier
The maximum activity of choline acetyltransferase (ChAT), the affinity for choline or acetyl-
CoA and the isozyme pattern in the cerebral cortex of 5 cases of Alzheimer type dementia …

CSF choline and acetylcholinesterase in early‐onset vs. late‐onset Alzheimer's disease patients

V Kumar, E Giacobini, S Markwell - Acta neurologica …, 1989 - Wiley Online Library
Cerebrospinal fluid acetylcholinesterase (AChE) activity levels and choline (Ch) levels were
studied in 52 dementia of Alzheimer type (DAT) patients and 20 age‐matched controls. The …

Neurotransmitter-related enzymes in senile dementia of the Alzheimer type

P Davies - Brain research, 1979 - Elsevier
Abstract Choline acetyltransferase (ChAT), acetylcholinesterase (AChE) and glutamic acid
decar☐ ylase (GAD) activities were measured in 20 brain regions from autopsied control and …

Choline acetyltransferase mRNA expression in the striatal neurons of patients with Alzheimer's disease

F Boissière, B Faucheux, Y Agid, EC Hirsch - Neuroscience letters, 1997 - Elsevier
Besides cortical pathology, Alzheimer's disease (AD) is associated with a massive loss of
cholinergic neurons in the basal forebrain. The resulting cortical cholinergic depletion is …

Changes in brain cholinesterases in senile dementia of Alzheimer type

EK PERRY, RH Perry, G Blessed… - Neuropathology and …, 1978 - Wiley Online Library
Acetyl‐and butyryl‐cholinesterase activities have been measured biochemically in normal
brain tissue, in senile dementia of Alzheimer type and in mental disorders without Alzheimer …

Reduced cholinesterase activity and somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with dementia of the Alzheimer type

HS Soininen, JT Jolkkonen, KJ Reinikainen… - Journal of the …, 1984 - Elsevier
Cholinesterase (ChE) activity and somatostatin-like immunoreactivity (SLI) of the
cerebrospinal fluid were determined for 59 patients with dementia of the Alzheimer type …