Despite the remarkable success of highly active antiretroviral therapy (HAART) for the
treatment of HIV-1 infection, it now appears that the infection is intrinsically incurable with …

Recent studies on patients with a history of pre-HAART drug resistance, but currently on a
successful regimen, provided new insights into the dynamics of the latent cellular viral …

▪ Abstract A viral reservoir is a cell type or anatomical site in association with which a
replication-competent form of the virus accumulates and persists with more stable kinetic …

Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …

The latent reservoir presents a formidable therapeutic challenge because it allows the virus
to persist as genetic information in the form of a stably integrated provirus in an inherently …

The success of combination antiretroviral therapy for HIV-1 infection has generated interest
in mechanisms by which the virus can persist in the body despite the presence of drugs that …

Recent advances in characterizing cellular and anatomic reservoirs and compartments
influence approaches to antiretroviral treatment, the management of antiretroviral resistance …

The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced
morbidity and mortality associated with HIV-1. Initially there was hope that ART would be …

The use of highly active antiretroviral therapy (HAART) in the treatment of HIV-1-infected
individuals has provided a considerable amount of information regarding the dynamics of …

The discovery of a stable latent reservoir for HIV‐1 in resting memory CD4+ T cells provides
a mechanism for lifelong persistence of HIV‐1. The long‐lived latently infected cells persist …