Inflammation under sterile conditions is not well understood despite its importance in trauma
and autoimmune disease. To investigate this process we established mouse models of …

Rationale: Ozone is a common environmental air pollutant that contributes to
hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced …

Hyaluronan (HA) has diverse functions in normal lung homeostasis and pulmonary disease.
HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products …

Tissues must quickly recognize injury to respond to the rapid pace of microbial growth. In
skin, dermal microvascular endothelial cells must also react to danger signals from the …

Lung injury is associated with increased concentrations of hyaluronan (hyaluronic acid, HA).
HA modifies cell behavior through interaction with cell-associated receptors such as …

CD44 is a transmembrane adhesion molecule and hemopoietic CD44 has an essential role
in hyaluronan clearance and resolution of noninfectious lung injury. In this study, we …

Ozone is a common urban environmental air pollutant and significantly contributes to
hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced …

Background Toll-like receptor 4 (TLR4) is essential in lipopolysaccharide (LPS)-induced
fibroblast activation and collagen secretion in vitro. However, its effects on the process of …

Pulmonary fibrosis is an inflammation-driven lung disease with a poor prognosis and no
cure. Here we report that basal toll-like receptor 4 (TLR4) activity is critical for the resolution …

We recently found that low-molecular-weight hyaluronan was induced by cyclic stretch in
lung fibroblasts and accumulated in lungs from animals with ventilator-induced lung injury …