Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2
KR Taylor, K Yamasaki, KA Radek, A Di Nardo… - Journal of Biological …, 2007 - ASBMB
Inflammation under sterile conditions is not well understood despite its importance in trauma
and autoimmune disease. To investigate this process we established mouse models of …
and autoimmune disease. To investigate this process we established mouse models of …
TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation
S Garantziotis, Z Li, EN Potts, JY Lindsey… - American journal of …, 2010 - atsjournals.org
Rationale: Ozone is a common environmental air pollutant that contributes to
hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced …
hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced …
Role of hyaluronan and hyaluronan-binding proteins in lung pathobiology
FE Lennon, PA Singleton - American Journal of Physiology …, 2011 - journals.physiology.org
Hyaluronan (HA) has diverse functions in normal lung homeostasis and pulmonary disease.
HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products …
HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products …
Hyaluronan fragments stimulate endothelial recognition of injury through TLR4
KR Taylor, JM Trowbridge, JA Rudisill… - Journal of Biological …, 2004 - ASBMB
Tissues must quickly recognize injury to respond to the rapid pace of microbial growth. In
skin, dermal microvascular endothelial cells must also react to danger signals from the …
skin, dermal microvascular endothelial cells must also react to danger signals from the …
Expression and role of the hyaluronan receptor RHAMM in inflammation after bleomycin injury
A Zaman, Z Cui, JP Foley, H Zhao… - American journal of …, 2005 - atsjournals.org
Lung injury is associated with increased concentrations of hyaluronan (hyaluronic acid, HA).
HA modifies cell behavior through interaction with cell-associated receptors such as …
HA modifies cell behavior through interaction with cell-associated receptors such as …
CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages
CD44 is a transmembrane adhesion molecule and hemopoietic CD44 has an essential role
in hyaluronan clearance and resolution of noninfectious lung injury. In this study, we …
in hyaluronan clearance and resolution of noninfectious lung injury. In this study, we …
Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice
S Garantziotis, Z Li, EN Potts, K Kimata, L Zhuo… - Journal of Biological …, 2009 - ASBMB
Ozone is a common urban environmental air pollutant and significantly contributes to
hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced …
hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced …
Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study
ZY He, YS Zhu, H Jiang - Respiratory research, 2009 - Springer
Background Toll-like receptor 4 (TLR4) is essential in lipopolysaccharide (LPS)-induced
fibroblast activation and collagen secretion in vitro. However, its effects on the process of …
fibroblast activation and collagen secretion in vitro. However, its effects on the process of …
[HTML][HTML] TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury
Pulmonary fibrosis is an inflammation-driven lung disease with a poor prognosis and no
cure. Here we report that basal toll-like receptor 4 (TLR4) activity is critical for the resolution …
cure. Here we report that basal toll-like receptor 4 (TLR4) activity is critical for the resolution …
The role of hyaluronan synthase 3 in ventilator-induced lung injury
KJ Bai, AP Spicer, MM Mascarenhas, L Yu… - American journal of …, 2005 - atsjournals.org
We recently found that low-molecular-weight hyaluronan was induced by cyclic stretch in
lung fibroblasts and accumulated in lungs from animals with ventilator-induced lung injury …
lung fibroblasts and accumulated in lungs from animals with ventilator-induced lung injury …