Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-
fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia …

By virtue of its direct contact with the environment, the lung is constantly challenged by
infectious and non-infectious stimuli that necessitate a robust yet highly controlled host …

Mucus hypersecretion with elevated MUC5B mucin production is a pathologic feature in
many airway diseases associated with oxidative stress. In the present work, we evaluated …

Lung injury triggers an acute inflammatory response characterized by increased expression
and deposition of extracellular matrix (ECM) components such as fibronectin and collagen …

The goals of this study were to characterize the changes in chondroitin sulfate proteoglycans
and hyaluronan in lungs in acute response to gram-negative bacterial infection and to …

Acute lung injury (ALI) causes significant morbidity and mortality. Fibroproliferation in ALI
results in worse outcomes, but the mechanisms governing fibroproliferation remain poorly …