Most currently available antiepileptic drugs (AEDs) were developed by testing new
compounds in animal models of seizures. Increased knowledge of the cellular and …

Epileptogenesis, a process leading to a reduced threshold for seizures after transient brain
insults, as well as the mechanisms underlying the propensity to generate spontaneous …

Mesial temporal lobe epilepsy (MTLE) accounts for almost 80% of all temporal lobe epilepsy
(TLE) in which seizures originate from the medial or internal structures of the temporal lobe …

Epigenetic remodeling and modifications of chromatin structure by DNA methylation and
histone modifications represent central mechanisms for the regulation of neuronal gene …

The epilepsies are a complex group of disorders that can be caused by a myriad of genetic
and acquired factors. As such, identifying interventions that will prevent development of …

Epilepsy is a complex disease, characterized by the repeated occurrence of bursts of
electrical activity (seizures) in specific brain areas. The behavioral outcome of seizure …

Keypoints Numerous epilepsy genes have been identified in the last years, mostly in the
(rare) monogenic forms and thanks to the increased availability and the decreased cost of …

Epilepsy is a serious disorder of the central nervous system characterized by recurrent
seizures. There are many known causes of epilepsy, including genetic factors, brain …

The epilepsies are a clinically heterogeneous group of common brain diseases which are
refractory to pharmacotherapy in up to one-third of patients. The discovery of DNA variants …

Epilepsy represents a condition in which abnormal neuronal discharges or the
hyperexcitability of neurons occur with synchronicity, presenting a significant public health …