Methadone-associated overdose deaths have dramatically increased. In order to inform an
evidence-based clinical practice guideline to improve safety of methadone prescribing, the …

Methadone is used for the treatment of opioid addiction and for treatment of chronic pain.
The safety of methadone has been called into question by data indicating a large increase in …

The number of deaths associated with methadone use increased dramatically in parallel
with marked increases in its use, particularly for treatment of chronic pain. To develop a …

Methadone is an interesting analgesic for multiple reasons. The unique properties of the
agent, low cost and widespread availability have led to increases in methadone prescribing …

Preface ethadone is a medication valued for its effectiveness in reducing the mortality
associated with opioid addiction as well as the various medical and behavioral morbidities …

While methadone has been available for over 50 years, its use in opiate dependence has
overshadowed its use as an analgesic. Within the last 10-15 years, though, methadone has …

Methadone is highly effective in treating opioid dependence, and it is also used as an
analgesic for second-line management of chronic pain. However, recent increases in …

Background Methadone is well known for its long duration of action and propensity for
mortality after an overdose. The present research was aimed at evaluating the clinical …

The increasing involvement of methadone in accidental overdose deaths is the subject of
several recent reports. The federal government reported more methadone-related deaths in …

Objective. To identify and characterize methadone-related drug interactions, as well as
factors accounting for the variability in manifesting these interactions clinically. Design …