Despite the early loss of glycemic differences between the original intensive therapy group
and conventional treatment in the DCCT/EDIC and UKPDS 80 trials, a continued reduction …

There is a growing body of evidence that cumulative hyperglycemic exposure plays a central
role in the development and progression of atherosclerotic cardiovascular disease in …

Accelerated atherosclerosis is the leading cause of coronary heart disease and stroke,
which could account for high mortality rates in patients with diabetes. Although several …

Unifying mechanisms for the consequences of aging and chronic diabetes are coming to
light with the identification that common to both settings is the production and accumulation …

Reactive derivatives of nonenzymatic glucose-protein condensation reactions, as well as
lipids and nucleic acids exposed to reducing sugars, form a heterogeneous group of …

Advanced glycation end products (AGEs) are a heterogenous group of molecules formed
during a non-enzymatic reaction between proteins and sugar residues. Recently, AGEs and …

Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal
failure, a variety of neuropathies and accelerated atherosclerosis, which could account for …

Advanced glycation end products (AGEs) interact with the receptor for AGEs (RAGE) on the
membrane and induce deleterious effects via activation of nuclear factor kappa-B, and …

Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal
failure, a variety of neuropathies and accelerated atherosclerosis, which could account for …

The enhanced generation and accumulation of advanced glycation endproducts (AGEs)
have been linked to increased risk for macrovascular and microvascular complications …