Neuroprotection and neuroregeneration of retinal ganglion cells after intravitreal carbon monoxide release
J Stifter, F Ulbrich, U Goebel, D Böhringer… - PloS one, 2017 - journals.plos.org
Purpose Retinal ischemia induces apoptosis leading to neurodegeneration and vision
impairment. Carbon monoxide (CO) in gaseous form showed cell-protective and anti …
impairment. Carbon monoxide (CO) in gaseous form showed cell-protective and anti …
The CORM ALF-186 mediates anti-apoptotic signaling via an activation of the p38 MAPK after ischemia and reperfusion injury in retinal ganglion cells
F Ulbrich, KB Kaufmann, A Meske, WA Lagrèze… - PLoS …, 2016 - journals.plos.org
Purpose Ischemia and reperfusion injury may induce apoptosis and lead to sustained tissue
damage and loss of function, especially in neuronal organs. While carbon monoxide is …
damage and loss of function, especially in neuronal organs. While carbon monoxide is …
Postconditioning with inhaled carbon monoxide counteracts apoptosis and neuroinflammation in the ischemic rat retina
N Schallner, M Fuchs, CI Schwer, T Loop, H Buerkle… - 2012 - journals.plos.org
Purpose Ischemia and reperfusion injury (I/R) of neuronal structures and organs is
associated with increased morbidity and mortality due to neuronal cell death. We …
associated with increased morbidity and mortality due to neuronal cell death. We …
[HTML][HTML] Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury
J Biermann, WA Lagrèze, C Dimitriu… - … & visual science, 2010 - tvst.arvojournals.org
Purpose.: Retinal ischemia/reperfusion (I/R) injury damages retinal neurons. Carbon
monoxide (CO) recently attracted attention as cytoprotective because of its anti-inflammatory …
monoxide (CO) recently attracted attention as cytoprotective because of its anti-inflammatory …
The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ss1 in rats' retinal …
F Ulbrich, C Hagmann, H Buerkle, CC Romao… - Journal of …, 2017 - Springer
Background The endogenously produced gaseous molecule carbon monoxide is able to
promote organ protection after ischemia-reperfusion injuries (IRI). The impact of carbon …
promote organ protection after ischemia-reperfusion injuries (IRI). The impact of carbon …
Carbon monoxide treatment reduces microglial activation in the ischemic rat retina
F Ulbrich, U Goebel, D Böhringer… - Graefe's Archive for …, 2016 - Springer
Purpose Ischemia and reperfusion (I/R) injury damages retinal neurons. Retinal injury is
accompanied by activation of microglia, which scavenge the dead or dying neurons, but …
accompanied by activation of microglia, which scavenge the dead or dying neurons, but …
Effects of intravitreal injection of a Rho-GTPase inhibitor (BA-210), or CNTF combined with an analogue of cAMP, on the dendritic morphology of regenerating retinal …
ES Drummond, J Rodger, M Penrose… - Restorative …, 2014 - content.iospress.com
Purpose: In adult rats, intravitreal injections of the Rho-GTPase inhibitor C3 transferase (BA-
210), or a cocktail of recombinant ciliary neurotrophic factor (CNTF) and a cyclic AMP …
210), or a cocktail of recombinant ciliary neurotrophic factor (CNTF) and a cyclic AMP …
Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor …
M Leibinger, A Müller, A Andreadaki… - Journal of …, 2009 - Soc Neuroscience
After optic nerve injury retinal ganglion cells (RGCs) normally fail to regenerate axons in the
optic nerve and undergo apoptosis. However, lens injury (LI) or intravitreal application of …
optic nerve and undergo apoptosis. However, lens injury (LI) or intravitreal application of …
Staining of fluorogold-prelabeled retinal ganglion cells with calcein-AM: A new method for assessing cell vitality
P Grieshaber, WA Lagrèze, C Noack… - Journal of neuroscience …, 2010 - Elsevier
PURPOSE: The number of retinal ganglion cells (RGC) is often used as an outcome
measure in neuroprotection. The gold standard for staining RGC is retrograde labeling, eg …
measure in neuroprotection. The gold standard for staining RGC is retrograde labeling, eg …
Imaging mouse retinal ganglion cells and their loss in vivo by a fundus camera in the normal and ischemia-reperfusion model
H Murata, M Aihara, YN Chen, T Ota… - … & visual science, 2008 - iovs.arvojournals.org
purpose. To visualize retinal ganglion cells (RGCs) and their gradual loss in the living
mouse. methods. With the use of B6. Cg-Tg (Thy1-CFP) 23Jrs/J mice, which express cyan …
mouse. methods. With the use of B6. Cg-Tg (Thy1-CFP) 23Jrs/J mice, which express cyan …