Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies

K Wang, FM Kievit, M Zhang - Pharmacological research, 2016 - Elsevier
Compared to conventional treatments, gene therapy offers a variety of advantages for
cancer treatment including high potency and specificity, low off-target toxicity, and delivery of …

Production and clinical development of nanoparticles for gene delivery

J Chen, Z Guo, H Tian, X Chen - Molecular Therapy Methods & Clinical …, 2016 - cell.com
Gene therapy is a promising strategy for specific treatment of numerous gene-associated
human diseases by intentionally altering the gene expression in pathological cells. A …

Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy

AJ Mukalel, RS Riley, R Zhang, MJ Mitchell - Cancer letters, 2019 - Elsevier
Immunotherapy has recently emerged as a powerful tool for cancer treatment. Early clinical
successes from cancer immunotherapy have led to a growing list of FDA approvals, and …

Nanoparticle drug delivery systems for synergistic delivery of tumor therapy

D Chen, X Liu, X Lu, J Tian - Frontiers in Pharmacology, 2023 - frontiersin.org
Nanoparticle drug delivery systems have proved anti-tumor effects; however, they are not
widely used in tumor therapy due to insufficient ability to target specific sites, multidrug …

Targeted polymeric nanoparticles for cancer gene therapy

J Kim, DR Wilson, CG Zamboni… - Journal of drug targeting, 2015 - Taylor & Francis
In this article, advances in designing polymeric nanoparticles for targeted cancer gene
therapy are reviewed. Characterization and evaluation of biomaterials, targeting ligands …

Will nanotechnology bring new hope for gene delivery?

JKL Wong, R Mohseni, AA Hamidieh… - Trends in …, 2017 - cell.com
The high mortality rates of cancer patients receiving standard treatments emphasize the
crucial need for alternative treatments. One promising strategy is to use organic …

Nanoparticle delivery systems for DNA/RNA and their potential applications in nanomedicine

H Shen, X Huang, J Min, S Le, Q Wang… - Current topics in …, 2019 - ingentaconnect.com
The rapid development of nanotechnology has a great influence on the fields of biology,
physiology, and medicine. Over recent years, nanoparticles have been widely presented as …

Nanoparticles for gene delivery: therapeutic and toxic effects

YS Choi, MY Lee, AE David, YS Park - Molecular & cellular toxicology, 2014 - Springer
Gene therapy has drawn significant attention as a potential method for treating both acute
illnesses and chronic diseases. Current research efforts have focused on developing …

Recent advances in nanoparticle-based cancer drug and gene delivery

N Amreddy, A Babu, R Muralidharan… - Advances in cancer …, 2018 - Elsevier
Effective and safe delivery of anticancer agents is among the major challenges in cancer
therapy. The majority of anticancer agents are toxic to normal cells, have poor bioavailability …

Non-viral nucleic acid containing nanoparticles as cancer therapeutics

KL Kozielski, Y Rui, JJ Green - Expert opinion on drug delivery, 2016 - Taylor & Francis
Introduction: The delivery of nucleic acids such as DNA and short interfering RNA (siRNA) is
promising for the treatment of many diseases, including cancer, by enabling novel biological …