[HTML][HTML] Xanthine oxidoreductase: A leading actor in cardiovascular disease drama
Cardiovascular diseases (CVD) are the leading cause of global mortality and their
pathogenesis lies mainly in the atherosclerotic process. There are close connections linking …
pathogenesis lies mainly in the atherosclerotic process. There are close connections linking …
[HTML][HTML] Xanthine oxidoreductase: One enzyme for multiple physiological tasks
Human xanthine oxidoreductase (XOR) is a multiple-level regulated enzyme, resulting from
a complicated evolutionary process that assigned it many physiological roles. The main …
a complicated evolutionary process that assigned it many physiological roles. The main …
[HTML][HTML] Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress
MG Battelli, L Polito, A Bolognesi - Atherosclerosis, 2014 - Elsevier
Endothelial xanthine oxidoreductase (XOR) together with NAD (P) H oxidase and nitric
oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO …
oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO …
Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications
CE Berry, JM Hare - The Journal of physiology, 2004 - Wiley Online Library
There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …
cardiovascular disease. Biochemical, molecular and pharmacological studies further …
Xanthine oxidoreductase: a journey from purine metabolism to cardiovascular excitation-contraction coupling
Xanthine oxidoreductase (XOR) is a ubiquitous complex cytosolic molybdoflavoprotein
which controls the rate limiting step of purine catabolism by converting xanthine to uric acid …
which controls the rate limiting step of purine catabolism by converting xanthine to uric acid …
[HTML][HTML] Chronic kidney disease: Which role for xanthine oxidoreductase activity and products?
The present review explores the role of xanthine oxidoreductase (XOR) in the development
and progression of chronic kidney disease (CKD). Human XOR is a multi-level regulated …
and progression of chronic kidney disease (CKD). Human XOR is a multi-level regulated …
Xanthine oxidase and uric acid in cardiovascular disease: clinical impact and therapeutic options
W Doehner, U Landmesser - Seminars in nephrology, 2011 - Elsevier
The association between increased uric acid (UA) levels and cardiovascular disease (CVD)
has been observed and studied for many decades. The value of UA as an independent …
has been observed and studied for many decades. The value of UA as an independent …
[HTML][HTML] The role of xanthine oxidoreductase and uric acid in metabolic syndrome
Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome
through the oxidative stress and the inflammatory response induced by XOR-derived …
through the oxidative stress and the inflammatory response induced by XOR-derived …
[HTML][HTML] Hyperuricemia and endothelial function: From molecular background to clinical perspectives
T Maruhashi, I Hisatome, Y Kihara, Y Higashi - Atherosclerosis, 2018 - Elsevier
Uric acid is the end product of purine metabolism catalyzed by xanthine oxidase in humans.
In the process of purine metabolism, reactive oxygen species, including superoxide, are …
In the process of purine metabolism, reactive oxygen species, including superoxide, are …
[HTML][HTML] Pathophysiology of circulating xanthine oxidoreductase: new emerging roles for a multi-tasking enzyme
MG Battelli, A Bolognesi, L Polito - … Acta (BBA)-Molecular Basis of Disease, 2014 - Elsevier
The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …