Neurons in the adult mammalian CNS do not spontaneously regenerate axons after injury
due to CNS myelin and other inhibitory factors. Previous studies have showed that inhibition …

Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small
GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such …

Spontaneous axonal regeneration of neurons does not occur after spinal cord injury
because of inhibition by myelin and other inhibitory factors. Studies have demonstrated that …

RhoA is a small GTPase that regulates many functions of mammalian cells via actin
reorganization. Lots of studies uncovered that its activation acts as a major negative …

Abstract The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK)
pathway is a major signaling pathway in the central nervous system, transducing inhibitory …

Publisher Summary This chapter discusses the inactivation of intracellular Rho to stimulate
axon growth and regeneration. In tissue culture, inactivation of the Rho signaling pathway is …

The Rho signaling pathway regulates the cytoskeleton and motility and plays an important
role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its …

Several major advances in our understanding of axon regeneration and functional repair in
the central nervous system (CNS) together with new insights about molecular signaling …

Abstract The small GTPase RhoA and its down-stream effector Rho-kinase (ROCK) are
important effector molecules of the neuronal cytoskeleton. Modulation of the RhoA/ROCK …

Rho-kinase (ROCK) is a serine/threonine kinase and one of the major downstream effectors
of the small GTPase Rho. The Rho-ROCK pathway is involved in many aspects of neuronal …