During the aging process, bone marrow mesenchymal stem cells (BMSCs) exhibit declined
osteogenesis accompanied by excess adipogenesis, which will lead to osteoporosis. Here …

Human bone marrow mesenchymal stem/stromal cells (MSCs) are multipotent progenitor
cells with multilineage differentiation potentials including osteogenesis and adipogenesis …

Skeletal aging is a complex process, characterized by a decrease in bone formation, an
increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a heterochromatin …

Epigenetic mechanisms regulate osteogenic lineage differentiation of mesenchymal stromal
cells. Histone methylation is controlled by multiple lysine demethylases and is an important …

Human adipose-derived stem cells (hASCs) are a highly attractive source in bone tissue
engineering. It has become increasingly clear that chromatin regulators play an important …

Recent emerging evidences revealed that epigenetic methylation of histone and DNA
regulates the lineage commitment of mesenchymal progenitor cells. This study was …

Abstract N6-methyladenosine (m6A) methylation, a well-known modification with new
epigenetic functions, has been reported to participate in the progression of osteoporosis …

Mesenchymal stem cells (MSCs) are characterized by their self-renewing capacity and
differentiation potential into multiple tissues. Thus, management of the differentiation …

Epigenetic modifications play a central role in cell differentiation and development. In the
current study, we have recognized lysine demethylase 4A (KDM4A) as a novel epigenetic …

Abstract Bone morphogenetic protein 2 (BMP2) has been used to induce bone regeneration
by promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells …