Introduction: Interethnic admixture is a source of cryptic population structure that may lead to
spurious genotype–phenotype associations in pharmacogenomic studies. We studied the …

The most widely studied polymorphisms of the ABCB1 gene are rs1128503 (c. 1236C> T),
rs2032582 (c. 2677G> T/A), and rs1045642 (c. 3435C> T). Although variation in ABCB1 …

Introduction: The human multidrug resistance gene ATP-binding cassette B1 (ABCB1) codes
for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer …

As functional ABCB1 haplotypes were recently reported in the promoter region of the gene,
we resequenced the ABCB1 distal promoter region, along with other regions (the enhancer …

The ATP‐binding cassette (ABC) transporter ABCB1, or P‐glycoprotein, is a transmembrane
efflux pump well known for its implication in drug transport and chemoresistance. ABCB1 …

Objective Promoter single-nucleotide polymorphisms (SNPs) of the ABCB1 gene, encoding
the placental efflux transporter P-glycoprotein, can affect its expression and alter xenobiotic …

BACKGROUND: While involvement of ABCB1 is well known in drug transport, its metabolite
transport role is not so well understood. Like other ABC transporters, ABCB1 might be …

In order to comprehensively screen genetic variants leading to differential expression of the
important human ABCB1 gene in the primary drug-metabolizing organ, ABCB1 mRNA …

Objective The ABCB1 (MDR1) gene, encoding the transporter P-glycoprotein, is known to
act on a broad range of prescription medicines. For this reason a large number of studies …

Background As a major mediator in the complex interplay between humans and the
xenobiotic environment, the ABCBI transporter gene is an obvious candidate for …