Increases in plasma n-3 tetracosapentaenoic acid and tetracosahexaenoic acid following 12 weeks of EPA, but not DHA, supplementation in women and men

RD Rotarescu, K Rezaei, DM Mutch… - … and Essential Fatty Acids, 2022 - Elsevier
Dietary feeding and stable isotope studies in rodents support that the 24-carbon omega-3
polyunsaturated fatty acids, tetracosapentaenoic acid (24: 5n-3, TPAn-3) and …

α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans

JT Brenna, N Salem Jr, AJ Sinclair… - … leukotrienes and essential …, 2009 - Elsevier
Blood levels of polyunsaturated fatty acids (PUFA) are considered biomarkers of status.
Alpha-linolenic acid, ALA, the plant omega-3, is the dietary precursor for the long-chain …

[HTML][HTML] Sex-specific differences in essential fatty acid metabolism

T Decsi, K Kennedy - The American journal of clinical nutrition, 2011 - Elsevier
Sex hormones may influence the enzymatic synthesis of long-chain polyunsaturated fatty
acids (LC-PUFAs), which may lead to sex-specific differences in LC-PUFA status. Isotope …

Effects of dietary α-linolenic acid treatment and the efficiency of its conversion to eicosapentaenoic and docosahexaenoic acids in obesity and related diseases

M Takic, B Pokimica, G Petrovic-Oggiano, T Popovic - Molecules, 2022 - mdpi.com
The essential fatty acid alpha-linolenic acid (ALA) is present in high amounts in oils such as
flaxseed, soy, hemp, rapeseed, chia, and perilla, while stearidonic acid is abundant in …

Metabolism and functional effects of plant-derived omega-3 fatty acids in humans

EJ Baker, EA Miles, GC Burdge, P Yaqoob… - Progress in lipid …, 2016 - Elsevier
Alpha-linolenic acid (ALA) is an essential fatty acid and the substrate for the synthesis of
longer-chain, more unsaturated ω-3 fatty acids, eicosapentaenoic acid (EPA) …

Sex hormones and n-3 fatty acid metabolism

CE Childs - Proceedings of the Nutrition Society, 2020 - cambridge.org
α-Linolenic acid (ALA) is an n-3 fatty acid found in plant-derived foods such as linseeds and
linseed oil. Mammals can convert this essential fatty acid into longer-chain fatty acids …

Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-γ-linolenic and eicosapentaenoic acid in plasma of …

YA Liou, SM Innis - Prostaglandins, leukotrienes and essential fatty acids, 2009 - Elsevier
High intakes of linoleic acid (LA, 18: 2n-6) have raised concern due to possible increase in
arachidonic acid (ARA, 20: 4n-6) synthesis, and inhibition of alpha linolenic acid (ALA, 18 …

Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review

BS Rett, J Whelan - Nutrition & metabolism, 2011 - Springer
Background Linoleic acid, with a DRI of 12-17 g/d, is the most highly consumed
polyunsaturated fatty acid in the Western diet and is found in virtually all commonly …

Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects

PLL Goyens, RP Mensink - European journal of clinical nutrition, 2006 - nature.com
Objective: To compare the effects of alpha-linolenic acid (ALA, C18: 3n-3) to those of
eicosapentaenoic acid (EPA, C20: 5n-3) plus docosahexaenoic acid (DHA, C22: 6n-3) on …

Quantitation of Human Whole‐Body Synthesis‐Secretion Rates of Docosahexaenoic Acid and Eicosapentaenoate Acid from Circulating Unesterified α‐Linolenic Acid …

YH Lin, JR Hibbeln, AF Domenichiello, CE Ramsden… - Lipids, 2018 - Wiley Online Library
The rate at which dietary α‐linolenic acid (ALA) is desaturated and elongated to its longer‐
chain n‐3 polyunsaturated fatty acid (PUFA) in humans is not agreed upon. In this study, we …