Citrulline protects human retinal pigment epithelium from hydrogen peroxide and iron/ascorbate induced damages

C Hassel, M Couchet, N Jacquemot… - Journal of Cellular …, 2022 - Wiley Online Library
Oxidative stress plays an important role in the ageing of the retina and in the pathogenesis
of retinal diseases such as age‐related macular degeneration (ARMD). Hydrogen peroxide …

[HTML][HTML] Cytoprotective effects of natural highly bio-available vegetable derivatives on human-derived retinal cells

I Munia, L Gafray, MA Bringer, P Goldschmidt… - Nutrients, 2020 - mdpi.com
Retinal pigment epithelial cells are crucial for retina maintenance, making their
cytoprotection an excellent way to prevent or slow down retinal degeneration. In addition …

[HTML][HTML] Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium …

JH Ha, PK Shil, P Zhu, L Gu, Q Li, S Chung - The Journal of nutrition, 2014 - Elsevier
Inflammation and endoplasmic reticulum (ER) stress are common denominators for vision-
threatening diseases such as diabetic retinopathy and age-related macular degeneration …

New lipophenols prevent carbonyl and oxidative stresses involved in macular degeneration

E Moine, M Boukhallat, D Cia, N Jacquemot… - Free Radical Biology …, 2021 - Elsevier
Dry age-related macular degeneration and Stargardt disease undergo a known toxic
mechanism caused by carbonyl and oxidative stresses (COS). This is responsible for …

[HTML][HTML] Flavonoids protect retinal ganglion cells from oxidative stress–induced death

P Maher, A Hanneken - Investigative ophthalmology & visual …, 2005 - arvojournals.org
purpose. Mounting evidence suggests that oxidative stress contributes to the pathogenesis
of many ocular diseases, including glaucoma and diabetic retinopathy. No treatments are …

Combination of Lutein and Zeaxanthin, and DHA Regulated Polyunsaturated Fatty Acid Oxidation in H2O2-Stressed Retinal Cells

HH Leung, JM Galano, C Crauste, T Durand… - Neurochemical …, 2020 - Springer
Photochemical and oxidative damages in retinal pigment epithelial (RPE) cells are key
events in the pathogenesis of age-related macular degeneration. Polyunsaturated fatty acids …

Plant flavonol quercetin and isoflavone biochanin A differentially induce protection against oxidative stress and inflammation in ARPE-19 cells

NMM Saviranta, L Veeroos, LJ Granlund… - Food Research …, 2011 - Elsevier
In this work, differential ability of plant flavonol quercetin and plant isoflavone biochanin A to
modulate oxidative stress and inhibit inflammation-related responses was investigated using …

[HTML][HTML] Inflammation, a double-edge sword for cancer and other age-related diseases

SC Gupta, AB Kunnumakkara, S Aggarwal… - Frontiers in …, 2018 - frontiersin.org
Increasing evidence from diverse sources during the past several years has indicated that
long-term, low level, chronic inflammation mediates several chronic diseases including …

[HTML][HTML] Functional diversity of flavonoids in the inhibition of the proinflammatory NF-κB, IRF, and Akt signaling pathways in murine intestinal epithelial cells

PA Ruiz, D Haller - The Journal of nutrition, 2006 - Elsevier
The molecular understanding of nutritional factors in the process of host factor–mediated
activation of the intestinal epithelium may play an important role in the assessment of …

Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation of endoplasmic reticulum stress

DC da Silva, PJ Jervis, JA Martins, P Valentão… - International …, 2023 - Elsevier
Inflammation and endoplasmic reticulum (ER) stress are often hand in hand in the context of
chronic disease. Both are activated upon perceived disturbances in homeostasis, being …