Phlorotannins are polyphenolic compounds in marine alga, especially the brown algae.
Among numerous phlorotannins, dieckol and phlorofucofuroeckol-A (PFF-A) are the major …

Modulation of multiple protein targets with a single compound is essential for the effective
treatment of central nervous system disorders. In our previous G protein-coupled receptor …

Polo-like kinase-1 (PLK-1) is an essential mitotic serine/threonine (Ser/Thr) kinase that
belongs to the Polo-like kinase (PLK) family and is overexpressed in non-small cell lung …

Over the past year, owing to the emergent demand for the search for potential COVID-19
therapeutics, identifying alternative candidates from biological sources is one of the …

Fucales are an order within the Phaeophyceae that include most of the common littoral
seaweeds in temperate and subtropical coastal regions. Many species of this order have …

This study aims to manifest the effect of the active compound phlorotannins in brown algae
on decreasing insulin resistance by analyzing the predicted interaction between …

Faced with the growing demands for natural products, the marine environment is a potential
source for the discovery of therapeutic compounds. The aim of this study was to evaluate the …

Background: Dimeric acylphloroglucinols occurring in species from sections Brathys and
Trigynobrathys of the genus Hypericum exhibit acylfilicinic acid and acylphloroglucinol …

Phlorotannins are a group of complex polymers of phloroglucinol (1, 3, 5-trihydroxybenzene)
unique to macroalgae. These phenolic compounds are integral structural components of the …

Glucagon-like peptide 1 receptor agonists (GLP-1RA) have excellent performance in the
treatment of diabetes, but the drugs used in the clinic are all macromolecular peptide …