Abstract Background: A previous PET-CT imaging study of 14 bronchoconstricted asthmatic
subjects showed that peripheral aerosol deposition was highly variable among subjects and …

Background: Computer modeling is used to predict inhaled aerosol deposition in the lung
based on definition of the aerosol characteristics and the breathing pattern and airway …

Radioactive aerosol work has identified factors which crucially affect patterns of inhaled
particle deposition within the lung. For many sizes and types of particle, gamma camera …

We studied deposition of radioactive monodisperse 1.5-micron aerosol in humans following
inhalation during quiet breathing. Two groups were studied: normal, defined by tidal loops …

Background: While it is generally accepted that inertial impaction will lead to particle loss as
aerosol is being carried into the pulmonary airways, most predictive aerosol deposition …

Background: This article presents a novel methodological approach to evaluate images of
aerosol deposition taken with PET-CT cameras. Traditionally, Black-or-White (BW) Regions …

Background: To provide a validation dataset for aerosol deposition modeling, a clinical trial
was performed in which the inhalation parameters and the inhaled aerosol were controlled …

The efficacy of inhaled pharmaceuticals depends, in part, on their site of respiratory
deposition. Markedly nonuniform ventilation distribution may occur in persons with …

The success of inhalation therapy is not only dependent upon the pharmacology of the
drugs being inhaled but also upon the site and extent of deposition in the respiratory tract …

Severe chronic obstructive pulmonary disease is associated with central deposition of
inhaled aerosols. This pattern may be due to functional narrowing of the large airways …