Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics
A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
Drug repurposing in cancer
L Sleire, HE Førde, IA Netland, L Leiss, BS Skeie… - Pharmacological …, 2017 - Elsevier
Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …
increase in the coming years. Whereas the limited success with current therapies has driven …
Drug repurposing for cancer therapy, easier said than done
A Gonzalez-Fierro, A Dueñas-González - Seminars in cancer biology, 2021 - Elsevier
Drug repurposing for cancer therapy is currently a hot topic of research. Theoretically, in
contrast to the known hurdles of developing new molecular entities, the approach of …
contrast to the known hurdles of developing new molecular entities, the approach of …
Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
Old wine in new bottles: Drug repurposing in oncology
M Antoszczak, A Markowska, J Markowska… - European Journal of …, 2020 - Elsevier
Increasing costs, much time consumption and high risk of failure associated with the process
of de novo development of new anticancer drugs have prompted the pharmaceutical …
of de novo development of new anticancer drugs have prompted the pharmaceutical …
Cancer drug discovery by repurposing: teaching new tricks to old dogs
Progressively increasing failure rates, high cost, poor bioavailability, poor safety, limited
efficacy, and a lengthy design and testing process associated with cancer drug development …
efficacy, and a lengthy design and testing process associated with cancer drug development …
Repurposing drugs in oncology: next steps
C Verbaanderd, L Meheus, I Huys, P Pantziarka - Trends in cancer, 2017 - cell.com
The repurposing of existing non-cancer drugs is a potential source of new treatment options
for cancer patients with high unmet medical needs. While scientific research is progressing …
for cancer patients with high unmet medical needs. While scientific research is progressing …
Repurposing old drugs in oncology: Opportunities with clinical and regulatory challenges ahead
RR Shah, PD Stonier - Journal of clinical pharmacy and …, 2019 - Wiley Online Library
What is known and objective In order to expedite the availability of drugs to treat cancers in a
cost‐effective manner, repurposing of old drugs for oncological indications is gathering …
cost‐effective manner, repurposing of old drugs for oncological indications is gathering …
[HTML][HTML] Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions
L Fu, W Jin, J Zhang, L Zhu, J Lu, Y Zhen… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug repurposing or repositioning has been well-known to refer to the therapeutic
applications of a drug for another indication other than it was originally approved for …
applications of a drug for another indication other than it was originally approved for …
A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery
T Pillaiyar, S Meenakshisundaram, M Manickam… - European journal of …, 2020 - Elsevier
Drug repurposing is a strategy consisting of finding new indications for already known
marketed drugs used in various clinical settings or highly characterized compounds despite …
marketed drugs used in various clinical settings or highly characterized compounds despite …