Mitochondrial respiratory complex II (CII), also known as succinate dehydrogenase, plays a
critical role in mitochondrial metabolism. Known but low potency CII inhibitors are selectively …

Aims Cancer cells, due to the Warburg effect, are more dependent on glycolysis than normal
cells, so glycolytic inhibitor 3-bromopyruvic acid (3-BP) was proposed as a promising …

The indole-3-carbinol (I3C) displays anti-cancer/proliferative activities against human cancer
cells. Cellular proliferation is an event associated with the progress and its continuation. This …

Abstract Newly designed 4-aminoquinazoline derivatives (5a-f, 6a, b, 7, 8, 9, 10a-c, 11a, b,
12a, b and 13a, b) have been synthesized and evaluated for their potential multitarget …

Novel ionic Ag (I)− piperazinium nalidixic acid conjugate 1 was synthesized as a potential
antitumor agent and was thoroughly characterized by elemental analysis, FT-IR, 1H and …

In this work, we describe how stereochemically complex polycyclic compounds can be
generated by applying a synthetic sequence comprising an intramolecular Ugi reaction …

Multicomponent reactions (MCRs) are a valuable tool for the sustainable synthesis of new
molecules in a fast, effective and eco‐friendly manner, leading to the generation of …

We recently screened a series of new aziridines β-D-galactopyranoside derivatives for
selective anticancer activity and identified 2-methyl-2, 3-[N-(4-methylbenzenesulfonyl) imino] …

Background. Thiosemicarbazide derivates are considered potential compounds of the
antitumor drugs, with a large spectrum of biological properties. The aim of the research was …

Arsenicals have been widely used in the treatment of cancers such as leukemia and other
tumors. However, their side effects limit their clinical application. Stiripentol, a second-line …