Background: Large-scale genome-wide association studies (GWAS) have been successful
in identifying genes that contribute to common diseases and phenotypes. A GWAS of …

In candidate gene era, dozens of single-nucleotide polymorphisms (SNPs) within renin–
angiotensin–aldosterone system (RAAS) have been reported to be significantly associated …

Essential hypertension is considered to be a typical complex disease with multifactorial
etiology, which leads to inconsistent findings in genetic studies. One possibility of failure to …

Background Renin-angiotensin-aldosterone system (RAAS) is the most important endocrine
blood pressure control mechanism in our body, genes encoding components of this system …

Serine/threonine protein kinase 39 (STK39) gene has attracted much renewed interest since
the identification of its genetic variants in susceptibility to hypertension by Wang et al. in a …

Blood pressure, one of the important vital signs, is affected by multiple genetic and
environmental factors. Recently, several genome-wide association (GWA) studies have …

Background Hypertension affects about 1/3 of adults worldwide,~ 3.8 million in Taiwan, 160
million in China, and 1 billion worldwide. It is a major risk factor leading to stroke …

BACKGROUND The large-scale meta-analysis of genome-wide association study (GWAS)
recently identified a genomic locus where the genetic variant at rs820430 was strongly …

Essential hypertension causes high rates of morbidity and mortality, primarily due to its
complications, and its development is regulated by genetic risk and environmental factors …

BACKGROUND We aimed to examine the associations of voltage-dependent calcium-
channel genes CACNA1A and CACNA1C with blood pressure (BP) changes and …